{"doi":"10.1084/jem.20221042","title":"Ion channel TRPV2 is critical in enhancing B cell activation and function","abstract":"The function of transient receptor potential vanilloid (TRPV) cation channels governing B cell activation remains to be explored. We present evidence that TRPV2 is highly expressed in B cells and plays a crucial role in the formation of the B cell immunological synapse and B cell activation. Physiologically, TRPV2 expression level is positively correlated to influenza-specific antibody production and is low in newborns and seniors. Pathologically, a positive correlation is established between TRPV2 expression and the clinical manifestations of systemic lupus erythematosus (SLE) in adult and child SLE patients. Correspondingly, mice with deficient TRPV2 in B cells display impaired antibody responses following immunization. Mechanistically, the pore and N-terminal domains of TRPV2 are crucial for gating cation permeation and executing mechanosensation in B cells upon antigen stimulation. These processes synergistically contribute to membrane potential depolarization and cytoskeleton remodeling within the B cell immunological synapse, fostering efficient B cell activation. Thus, TRPV2 is critical in augmenting B cell activation and function.","journal":"The Journal of Experimental Medicine","year":2024,"id":423610,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":993308,"name":"Meng Zhao","orcid":"0000-0002-9967-7075","position":1,"is_corresponding":false},{"id":1219952,"name":"Xiaohang Liu","orcid":null,"position":2,"is_corresponding":false},{"id":1219341,"name":"Yuxin Li","orcid":"0009-0004-4928-3379","position":3,"is_corresponding":false},{"id":1219342,"name":"Bihua Xu","orcid":"0009-0002-5138-692X","position":4,"is_corresponding":false},{"id":332710,"name":"L. Zhou","orcid":"0000-0002-3838-1836","position":5,"is_corresponding":false},{"id":1022840,"name":"Xiaolin Sun","orcid":"0000-0001-9709-1532","position":6,"is_corresponding":false},{"id":1219343,"name":"Wenbo Sun","orcid":"0000-0003-3988-3990","position":7,"is_corresponding":false},{"id":1219344,"name":"Na Kang","orcid":"0000-0003-4771-0475","position":8,"is_corresponding":false},{"id":1219953,"name":"Zhenglin Ji","orcid":null,"position":9,"is_corresponding":false},{"id":1219345,"name":"Tong Li","orcid":"0009-0004-5738-6466","position":10,"is_corresponding":false},{"id":1219346,"name":"Haoran An","orcid":"0000-0002-5921-7402","position":11,"is_corresponding":false},{"id":807947,"name":"Fei Wang","orcid":"0000-0002-2513-502X","position":12,"is_corresponding":false},{"id":7853,"name":"Chuan Wu","orcid":"0000-0003-2288-353X","position":13,"is_corresponding":false},{"id":344450,"name":"Jingying Ye","orcid":"0000-0002-4022-6202","position":14,"is_corresponding":false},{"id":1219347,"name":"Jing‐Ren Zhang","orcid":"0000-0003-4973-4243","position":15,"is_corresponding":false},{"id":1219348,"name":"Qingwen Wang","orcid":"0000-0003-4303-8271","position":16,"is_corresponding":false},{"id":1219349,"name":"Xiaodong Zhao","orcid":"0000-0003-2054-8711","position":17,"is_corresponding":false},{"id":1219350,"name":"Zhanguo Li","orcid":"0000-0002-3421-6972","position":18,"is_corresponding":false},{"id":1219351,"name":"Wanli Liu","orcid":"0000-0003-0395-2800","position":19,"is_corresponding":false},{"id":1219340,"name":"Cuifeng Li","orcid":"0009-0001-1111-9061","position":0,"is_corresponding":true}],"reference_count":91,"raw_metadata":null,"created_at":"2026-07-19T01:58:01.889748Z","pmid":"38353705","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}