{"doi":"10.1084/jem.20212059","title":"Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation","abstract":"Acute cellular rejection is common after lung transplantation and is associated with an increased risk of early chronic rejection. We present combined single-cell RNA and TCR sequencing on recipient-derived T cells obtained from the bronchoalveolar lavage of three lung transplant recipients with rejection and compare them with T cells obtained from the same patients after treatment of rejection with high-dose systemic glucocorticoids. At the time of rejection, we found an oligoclonal expansion of cytotoxic CD8+ T cells that all persisted as tissue resident memory T cells after successful treatment. Persisting CD8+ allograft-resident T cells have reduced gene expression for cytotoxic mediators after therapy with glucocorticoids but accumulate around airways. This clonal expansion is discordant with circulating T cell clonal expansion at the time of rejection, suggesting in situ expansion. We thus highlight the accumulation of cytotoxic, recipient-derived tissue resident memory T cells within the lung allograft that persist despite the administration of high-dose systemic glucocorticoids. The long-term clinical consequences of this persistence have yet to be characterized.","journal":"The Journal of Experimental Medicine","year":2022,"id":239938,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":47,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9467,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":356570,"name":"Kaveh Moghbeli","orcid":"0000-0002-9047-5047","position":1,"is_corresponding":false},{"id":822265,"name":"Anna Bondonese","orcid":"0000-0001-9489-6052","position":2,"is_corresponding":false},{"id":822266,"name":"Andrew Craig","orcid":"0000-0003-3524-2029","position":3,"is_corresponding":false},{"id":490481,"name":"Iulia Popescu","orcid":"0000-0003-4294-1223","position":4,"is_corresponding":false},{"id":818388,"name":"Li Fan","orcid":"0000-0002-8764-3687","position":5,"is_corresponding":false},{"id":12145,"name":"Tracy Tabib","orcid":"0000-0003-4053-988X","position":6,"is_corresponding":false},{"id":7274,"name":"Robert Lafyatis","orcid":"0000-0002-9398-5034","position":7,"is_corresponding":false},{"id":279535,"name":"Kong Chen","orcid":"0000-0001-6980-5454","position":8,"is_corresponding":false},{"id":270564,"name":"Humberto E. Trejo Bittar","orcid":"0000-0003-2701-6531","position":9,"is_corresponding":false},{"id":822267,"name":"Elizabeth A. Lendermon","orcid":"0000-0002-7374-5674","position":10,"is_corresponding":false},{"id":380585,"name":"Joseph M. Pilewski","orcid":"0000-0002-0893-1155","position":11,"is_corresponding":false},{"id":822268,"name":"B. A. Johnson","orcid":"0000-0003-3922-2826","position":12,"is_corresponding":false},{"id":822269,"name":"S. Kilaru","orcid":"0000-0001-5181-4205","position":13,"is_corresponding":false},{"id":288811,"name":"Yingze Zhang","orcid":"0000-0001-6947-2901","position":14,"is_corresponding":false},{"id":345128,"name":"Pablo G. Sánchez","orcid":"0000-0003-3607-0345","position":15,"is_corresponding":false},{"id":58179,"name":"Jonathan K. Alder","orcid":"0000-0003-3741-6512","position":16,"is_corresponding":false},{"id":225061,"name":"Peter A. Sims","orcid":"0000-0002-3921-4837","position":17,"is_corresponding":false},{"id":58178,"name":"John F. McDyer","orcid":"0000-0003-0595-595X","position":18,"is_corresponding":false},{"id":728223,"name":"Mark E. Snyder","orcid":"0000-0002-0092-9296","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T00:22:41.699779Z","pmid":"35285873","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}