{"doi":"10.1084/jem.20210042","title":"Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function","abstract":"Obesity is one of the leading preventable causes of cancer; however, little is known about the effects of obesity on anti-tumor immunity. Here, we investigated the effects of obesity on CD8 T cells in mouse models and patients with endometrial cancer. Our findings revealed that CD8 T cell infiltration is suppressed in obesity, which was associated with a decrease in chemokine production. Tumor-resident CD8 T cells were also functionally suppressed in obese mice, which was associated with a suppression of amino acid metabolism. Similarly, we found that a high BMI negatively correlated with CD8 infiltration in human endometrial cancer and that weight loss was associated with a complete pathological response in six of nine patients. Moreover, immunotherapy using anti-PD-1 led to tumor rejection in lean and obese mice and partially restored CD8 metabolism and anti-tumor immunity. These findings highlight the suppressive effects of obesity on CD8 T cell anti-tumor immunity, which can partially be reversed by weight loss and/or immunotherapy.","journal":"The Journal of Experimental Medicine","year":2022,"id":234754,"datarank":0.6798899239729885,"base_score":4.532599493153256,"endowment":4.532599493153256,"self_citation_contribution":0.6798899239729885,"citation_network_contribution":0.0,"self_endowment_contribution":0.6798899239729885,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":92,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":85077,"name":"Hannah Prendeville","orcid":"0000-0003-3731-4372","position":1,"is_corresponding":false},{"id":85069,"name":"Mathilde Raverdeau","orcid":"0000-0002-6088-6902","position":2,"is_corresponding":false},{"id":851184,"name":"Mieszko M. Wilk","orcid":"0000-0002-7947-633X","position":3,"is_corresponding":false},{"id":85086,"name":"Róisín M. Loftus","orcid":"0000-0001-9137-6625","position":4,"is_corresponding":false},{"id":85075,"name":"Aaron Douglas","orcid":"0000-0002-8812-9575","position":5,"is_corresponding":false},{"id":851185,"name":"Janet McCormack","orcid":"0000-0001-6368-5295","position":6,"is_corresponding":false},{"id":851186,"name":"Bruce Moran","orcid":"0000-0002-7266-0265","position":7,"is_corresponding":false},{"id":851187,"name":"Michael Wilkinson","orcid":"0000-0002-4252-5097","position":8,"is_corresponding":false},{"id":228752,"name":"Evanna L. Mills","orcid":"0000-0003-0447-8995","position":9,"is_corresponding":false},{"id":851188,"name":"Michael Doughty","orcid":"0000-0002-5342-892X","position":10,"is_corresponding":false},{"id":851189,"name":"Aurélie Fabre","orcid":"0000-0001-8176-1386","position":11,"is_corresponding":false},{"id":851190,"name":"Helen Heneghan","orcid":"0000-0002-2009-3406","position":12,"is_corresponding":false},{"id":852091,"name":"Carel LeRoux","orcid":null,"position":13,"is_corresponding":false},{"id":851191,"name":"Andrew E. Hogan","orcid":"0000-0001-5875-230X","position":14,"is_corresponding":false},{"id":228757,"name":"Edward T. Chouchani","orcid":"0000-0002-9776-8790","position":15,"is_corresponding":false},{"id":851192,"name":"Donal O’Shea","orcid":"0000-0002-1408-5274","position":16,"is_corresponding":false},{"id":653566,"name":"Donal J. Brennan","orcid":"0000-0002-6747-3342","position":17,"is_corresponding":false},{"id":85084,"name":"Lydia Lynch","orcid":"0000-0002-4273-4681","position":18,"is_corresponding":false},{"id":85073,"name":"Lydia Dyck","orcid":"0000-0002-2548-9039","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:21:42.662304Z","pmid":"35103755","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}