{"doi":"10.1084/jem.20210021","title":"Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes","abstract":"IL-27 controls a diverse range of immune responses in many disease settings. Here, we identify intestinal epithelial cells (IECs) as one of the major IL-27 cellular sources in the gut-associated tissue. Unlike IL-27 secreted by innate immune cells, gut epithelial IL-27 is dispensable for T-bet+ regulatory T cell (T reg cell) differentiation or IL-10 induction. Rather, IEC-derived IL-27 specifically promotes a distinct CD8αα+CD4+ intraepithelial lymphocyte (IEL) population that acquires their functional differentiation at the intestinal epithelium. Loss of IL-27 in IECs leads to a selective defect in CD8αα+CD4+ IELs over time. Consequently, mice with IEC-specific IL-27 ablation exhibited elevated pathogen burden during parasitic infection, and this could be rescued by transfer of exogenous CD8αα+CD4+ IELs. Collectively, our data reveal that in addition to its known regulatory properties in preventing immune hyperactivity, gut epithelial IL-27 confers barrier immunity by inducing a specific IEL subset and further suggest that IL-27 produced by different cell types plays distinct roles in maintaining intestinal homeostasis.","journal":"The Journal of Experimental Medicine","year":2021,"id":168132,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9491,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":414230,"name":"Mei‐Chi Chen","orcid":"0000-0002-9984-3459","position":1,"is_corresponding":false},{"id":414229,"name":"Ling-Li Lin","orcid":"0000-0002-6547-4739","position":2,"is_corresponding":false},{"id":563020,"name":"David A. Christian","orcid":"0000-0002-7160-9900","position":3,"is_corresponding":false},{"id":278889,"name":"Booki Min","orcid":"0000-0002-2151-9413","position":4,"is_corresponding":false},{"id":305888,"name":"Christopher A. Hunter","orcid":"0000-0003-3092-1428","position":5,"is_corresponding":false},{"id":236080,"name":"Li‐Fan Lu","orcid":"0000-0002-9727-0036","position":6,"is_corresponding":false},{"id":696723,"name":"Chia‐Hao Lin","orcid":"0000-0001-6510-8483","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T23:46:02.603031Z","pmid":"34554189","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}