{"doi":"10.1084/jem.20202486","title":"Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine","abstract":"Yellow fever virus (YFV) live attenuated vaccine can, in rare cases, cause life-threatening disease, typically in patients with no previous history of severe viral illness. Autosomal recessive (AR) complete IFNAR1 deficiency was reported in one 12-yr-old patient. Here, we studied seven other previously healthy patients aged 13 to 80 yr with unexplained life-threatening YFV vaccine-associated disease. One 13-yr-old patient had AR complete IFNAR2 deficiency. Three other patients vaccinated at the ages of 47, 57, and 64 yr had high titers of circulating auto-Abs against at least 14 of the 17 individual type I IFNs. These antibodies were recently shown to underlie at least 10% of cases of life-threatening COVID-19 pneumonia. The auto-Abs were neutralizing in vitro, blocking the protective effect of IFN-α2 against YFV vaccine strains. AR IFNAR1 or IFNAR2 deficiency and neutralizing auto-Abs against type I IFNs thus accounted for more than half the cases of life-threatening YFV vaccine-associated disease studied here. Previously healthy subjects could be tested for both predispositions before anti-YFV vaccination.","journal":"The Journal of Experimental Medicine","year":2021,"id":146241,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":242,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9583,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":104141,"name":"Eleftherios Michailidis","orcid":"0000-0002-9907-4346","position":1,"is_corresponding":false},{"id":104142,"name":"Hans-Heinrich Hoffmann","orcid":"0000-0003-0554-0244","position":2,"is_corresponding":false},{"id":104473,"name":"Marwa Chbihi","orcid":"0000-0002-2771-851X","position":3,"is_corresponding":false},{"id":618891,"name":"Tom Le Voyer","orcid":"0000-0002-7253-3135","position":4,"is_corresponding":false},{"id":104146,"name":"Jérémie Rosain","orcid":"0000-0002-2822-161X","position":5,"is_corresponding":false},{"id":104145,"name":"Quentin Philippot","orcid":"0000-0003-3429-9605","position":6,"is_corresponding":false},{"id":104164,"name":"Yoann Seeleuthner","orcid":"0000-0002-1878-8567","position":7,"is_corresponding":false},{"id":615375,"name":"Adrian Gervais","orcid":"0000-0002-1083-5787","position":8,"is_corresponding":false},{"id":621357,"name":"Marie Materna","orcid":"0000-0003-1180-6651","position":9,"is_corresponding":false},{"id":621358,"name":"Patrícia Mouta Nunes de Oliveira","orcid":"0000-0001-6867-398X","position":10,"is_corresponding":false},{"id":622486,"name":"Maria de Lourdes S. 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