{"doi":"10.1084/jem.20201241","title":"Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling","abstract":"Severe acute respiratory syndrome-coronavirus 2 (SARS-Cov-2) has caused over 13,000,000 cases of coronavirus disease (COVID-19) with a significant fatality rate. Laboratory mice have been the stalwart of therapeutic and vaccine development; however, they do not support infection by SARS-CoV-2 due to the virus's inability to use the mouse orthologue of its human entry receptor angiotensin-converting enzyme 2 (hACE2). While hACE2 transgenic mice support infection and pathogenesis, these mice are currently limited in availability and are restricted to a single genetic background. Here we report the development of a mouse model of SARS-CoV-2 based on adeno-associated virus (AAV)-mediated expression of hACE2. These mice support viral replication and exhibit pathological findings found in COVID-19 patients. Moreover, we show that type I interferons do not control SARS-CoV-2 replication in vivo but are significant drivers of pathological responses. Thus, the AAV-hACE2 mouse model enables rapid deployment for in-depth analysis following robust SARS-CoV-2 infection with authentic patient-derived virus in mice of diverse genetic backgrounds.","journal":"The Journal of Experimental Medicine","year":2020,"id":48381,"datarank":0.9123328365564671,"base_score":6.082218910376446,"endowment":6.082218910376446,"self_citation_contribution":0.9123328365564671,"citation_network_contribution":0.0,"self_endowment_contribution":0.9123328365564671,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":437,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":105822,"name":"Eric Song","orcid":"0000-0001-5448-5865","position":1,"is_corresponding":false},{"id":105757,"name":"Tianyang Mao","orcid":"0000-0001-9251-8592","position":2,"is_corresponding":false},{"id":105760,"name":"Peiwen Lu","orcid":"0000-0001-6118-872X","position":3,"is_corresponding":false},{"id":105763,"name":"Amit Meir","orcid":"0000-0001-9635-1021","position":4,"is_corresponding":false},{"id":17339,"name":"Feimei Liu","orcid":"0000-0003-2663-6544","position":5,"is_corresponding":false},{"id":107015,"name":"Mia Madel Alfajaro","orcid":"0000-0002-6402-2730","position":6,"is_corresponding":false},{"id":110474,"name":"Jin Wei","orcid":"0000-0002-2832-1610","position":7,"is_corresponding":false},{"id":226474,"name":"Huiping Dong","orcid":"0000-0002-9447-0868","position":8,"is_corresponding":false},{"id":41685,"name":"Robert Homer","orcid":"0000-0002-2055-5885","position":9,"is_corresponding":false},{"id":17340,"name":"Aaron M. Ring","orcid":"0000-0003-3699-2446","position":10,"is_corresponding":false},{"id":107022,"name":"Craig B. Wilen","orcid":"0000-0003-2495-9403","position":11,"is_corresponding":false},{"id":105840,"name":"Akiko Iwasaki","orcid":"0000-0002-7824-9856","position":12,"is_corresponding":false},{"id":105753,"name":"Benjamin Israelow","orcid":"0000-0002-1308-8246","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T20:34:12.647743Z","pmid":"32750141","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}