{"doi":"10.1084/jem.20201214","title":"Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia","abstract":"We report that combination bNAb immunotherapy initiated on day 3 post-infection (PI) maintained durable CD8+ T cell-mediated suppression of SHIVAD8 viremia and preinoculation levels of CD4+ T cells in 9 of 13 treated monkeys during nearly 6 yr of observation, as assessed by successive CD8+ T cell-depletion experiments. In an extension of that study, two treatment interventions (bNAbs alone or cART plus bNAbs) beginning on week 2 PI were conducted and conferred controller status to 7 of 12 monkeys that was also dependent on control mediated by CD8+ cells. However, the median time to suppression of plasma viremia following intervention on week 2 was markedly delayed (85 wk) compared with combination bNAb immunotherapy initiated on day 3 (39 wk). In both cases, the principal correlate of virus control was the induction of CD8+ T cellular immunity.","journal":"The Journal of Experimental Medicine","year":2020,"id":66685,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":353332,"name":"Olivia K. Donau","orcid":"0000-0002-8184-7849","position":1,"is_corresponding":false},{"id":291260,"name":"Joana Dias","orcid":"0000-0002-1187-8770","position":2,"is_corresponding":false},{"id":353333,"name":"Sara Ferrando‐Martínez","orcid":"0000-0003-0721-555X","position":3,"is_corresponding":false},{"id":353334,"name":"Eric Jesteadt","orcid":"0000-0002-7501-4541","position":4,"is_corresponding":false},{"id":353335,"name":"Reza Sadjadpour","orcid":"0000-0003-3605-5196","position":5,"is_corresponding":false},{"id":353336,"name":"Rajeev Gautam","orcid":"0000-0003-2390-8727","position":6,"is_corresponding":false},{"id":353337,"name":"Alicia Buckler‐White","orcid":"0000-0003-3357-0328","position":7,"is_corresponding":false},{"id":353338,"name":"Romas Geleziunas","orcid":"0000-0002-9290-8811","position":8,"is_corresponding":false},{"id":290824,"name":"Richard A. Koup","orcid":"0000-0002-3090-7282","position":9,"is_corresponding":false},{"id":104187,"name":"Michel C. Nussenzweig","orcid":"0000-0003-0592-8564","position":10,"is_corresponding":false},{"id":353339,"name":"Malcolm A. Martin","orcid":"0000-0002-6845-9905","position":11,"is_corresponding":false},{"id":353331,"name":"Yoshiaki Nishimura","orcid":"0000-0003-1347-2368","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-18T21:14:50.590588Z","pmid":"32966579","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}