{"doi":"10.1084/jem.20200913","title":"Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma","abstract":"Immunotherapy has revolutionized the treatment of many tumors. However, most glioblastoma (GBM) patients have not, so far, benefited from such successes. With the goal of exploring ways to boost anti-GBM immunity, we developed a B cell-based vaccine (BVax) that consists of 4-1BBL+ B cells activated with CD40 agonism and IFNγ stimulation. BVax migrates to key secondary lymphoid organs and is proficient at antigen cross-presentation, which promotes both the survival and the functionality of CD8+ T cells. A combination of radiation, BVax, and PD-L1 blockade conferred tumor eradication in 80% of treated tumor-bearing animals. This treatment elicited immunological memory that prevented the growth of new tumors upon subsequent reinjection in cured mice. GBM patient-derived BVax was successful in activating autologous CD8+ T cells; these T cells showed a strong ability to kill autologous glioma cells. Our study provides an efficient alternative to current immunotherapeutic approaches that can be readily translated to the clinic.","journal":"The Journal of Experimental Medicine","year":2020,"id":58376,"datarank":0.6456097639806255,"base_score":4.304065093204169,"endowment":4.304065093204169,"self_citation_contribution":0.6456097639806255,"citation_network_contribution":0.0,"self_endowment_contribution":0.6456097639806255,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":73,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9443,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":294787,"name":"Jason Miska","orcid":"0000-0001-9608-2810","position":1,"is_corresponding":false},{"id":305715,"name":"David Hou","orcid":"0000-0002-1224-0146","position":2,"is_corresponding":false},{"id":305716,"name":"Aida Rashidi","orcid":"0000-0002-4555-1514","position":3,"is_corresponding":false},{"id":305717,"name":"Peng Zhang","orcid":"0000-0001-9856-7571","position":4,"is_corresponding":false},{"id":305718,"name":"Rachel A. Burga","orcid":"0000-0002-0204-8986","position":5,"is_corresponding":false},{"id":305719,"name":"Ignacio Jusué-Torres","orcid":"0000-0002-9749-1912","position":6,"is_corresponding":false},{"id":305720,"name":"Ting Xiao","orcid":"0000-0002-7502-4395","position":7,"is_corresponding":false},{"id":305721,"name":"Víctor A. Arrieta","orcid":"0000-0003-2738-9741","position":8,"is_corresponding":false},{"id":227991,"name":"Daniel Y. Zhang","orcid":"0000-0001-9962-9295","position":9,"is_corresponding":false},{"id":305722,"name":"Aurora Lopez‐Rosas","orcid":"0000-0001-6712-5738","position":10,"is_corresponding":false},{"id":291805,"name":"Yu Han","orcid":"0000-0003-0552-720X","position":11,"is_corresponding":false},{"id":271522,"name":"Adam M. Sonabend","orcid":"0000-0002-8347-1945","position":12,"is_corresponding":false},{"id":225603,"name":"Craig Horbinski","orcid":"0000-0001-8340-9992","position":13,"is_corresponding":false},{"id":7207,"name":"Roger Stupp","orcid":"0000-0002-5483-3118","position":14,"is_corresponding":false},{"id":305723,"name":"Irina V. Balyasnikova","orcid":"0000-0002-3903-9629","position":15,"is_corresponding":false},{"id":291806,"name":"Maciej S. Lesniak","orcid":"0000-0002-0096-5107","position":16,"is_corresponding":false},{"id":305714,"name":"Catalina Lee-Chang","orcid":"0000-0002-7675-2124","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:07:11.345501Z","pmid":"32991668","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}