{"doi":"10.1084/jem.20200318","title":"Liver X receptors are required for thymic resilience and T cell output","abstract":"The thymus is a primary lymphoid organ necessary for optimal T cell development. Here, we show that liver X receptors (LXRs)-a class of nuclear receptors and transcription factors with diverse functions in metabolism and immunity-critically contribute to thymic integrity and function. LXRαβ-deficient mice develop a fatty, rapidly involuting thymus and acquire a shrunken and prematurely immunoinhibitory peripheral T cell repertoire. LXRαβ's functions are cell specific, and the resulting phenotypes are mutually independent. Although thymic macrophages require LXRαβ for cholesterol efflux, thymic epithelial cells (TECs) use LXRαβ for self-renewal and thymocytes for negative selection. Consequently, TEC-derived LXRαβ protects against homeostatic premature involution and orchestrates thymic regeneration following stress, while thymocyte-derived LXRαβ limits cell disposal during negative selection and confers heightened sensitivity to experimental autoimmune encephalomyelitis. These results identify three distinct but complementary mechanisms by which LXRαβ governs T lymphocyte education and illuminate LXRαβ's indispensable roles in adaptive immunity.","journal":"The Journal of Experimental Medicine","year":2020,"id":102487,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":501822,"name":"Ashley M. Fenn","orcid":null,"position":1,"is_corresponding":false},{"id":501823,"name":"Nina K. Harder","orcid":null,"position":2,"is_corresponding":false},{"id":500586,"name":"John E. Mindur","orcid":"0000-0002-2212-3904","position":3,"is_corresponding":false},{"id":310364,"name":"Cameron S. McAlpine","orcid":"0000-0002-9832-6345","position":4,"is_corresponding":false},{"id":486783,"name":"Jyoti D. Patel","orcid":"0000-0002-7550-2094","position":5,"is_corresponding":false},{"id":349669,"name":"Colin Valet","orcid":null,"position":6,"is_corresponding":false},{"id":500587,"name":"Sara Rattik","orcid":"0000-0002-5172-6456","position":7,"is_corresponding":false},{"id":271225,"name":"Yoshiko Iwamoto","orcid":"0000-0002-3723-1043","position":8,"is_corresponding":false},{"id":500588,"name":"Shun He","orcid":"0000-0002-8389-9001","position":9,"is_corresponding":false},{"id":500589,"name":"Atsushi Anzai","orcid":"0000-0002-7474-1309","position":10,"is_corresponding":false},{"id":500590,"name":"Florian Kahles","orcid":"0000-0001-6343-2562","position":11,"is_corresponding":false},{"id":248976,"name":"Wolfram C. 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Sadreyev","orcid":"0000-0002-4240-5466","position":19,"is_corresponding":false},{"id":248977,"name":"Matthias Nahrendorf","orcid":"0000-0002-4021-1887","position":20,"is_corresponding":false},{"id":500595,"name":"Marit Westerterp","orcid":"0000-0003-2230-1659","position":21,"is_corresponding":false},{"id":349822,"name":"Alan R. Tall","orcid":"0000-0002-7708-2417","position":22,"is_corresponding":false},{"id":257516,"name":"Jan-Ακε Gustafsson","orcid":"0000-0002-1472-1373","position":23,"is_corresponding":false},{"id":248978,"name":"Filip K. Świrski","orcid":"0000-0002-3163-9152","position":24,"is_corresponding":false},{"id":500585,"name":"Christopher T. 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