{"doi":"10.1084/jem.20200030","title":"TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells","abstract":"In addition to Foxp3+ CD4+ regulatory T cells (CD4+ T reg cells), Foxp3- CD8+ regulatory T cells (CD8+ T reg cells) are critical to maintain immune tolerance. However, the molecular programs that specifically control CD8+ but not CD4+ T reg cells are largely unknown. Here, we demonstrate that simultaneous disruption of both TGF-β receptor and transcription factor Eomesodermin (Eomes) in T cells results in lethal autoimmunity due to a specific defect in CD8+ but not CD4+ T reg cells. Further, TGF-β signal maintains the regulatory identity, while Eomes controls the follicular location of CD8+ T reg cells. Both TGF-β signal and Eomes coordinate to promote the homeostasis of CD8+ T reg cells. Together, we have identified a unique molecular program designed for CD8+ T reg cells.","journal":"The Journal of Experimental Medicine","year":2020,"id":59686,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":66,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":314396,"name":"Wei Liao","orcid":"0000-0002-8828-011X","position":1,"is_corresponding":false},{"id":314397,"name":"Yong Liu","orcid":"0000-0001-5102-0309","position":2,"is_corresponding":false},{"id":314398,"name":"Ming Yang","orcid":"0000-0002-8560-0421","position":3,"is_corresponding":false},{"id":315978,"name":"Chaoyu Ma","orcid":null,"position":4,"is_corresponding":false},{"id":314399,"name":"Haijing Wu","orcid":"0000-0002-6338-5089","position":5,"is_corresponding":false},{"id":237108,"name":"Ming Zhao","orcid":"0000-0002-1320-1093","position":6,"is_corresponding":false},{"id":314400,"name":"Xin Zhang","orcid":"0000-0002-9273-6212","position":7,"is_corresponding":false},{"id":314401,"name":"Yuanzheng Qiu","orcid":"0000-0001-9518-388X","position":8,"is_corresponding":false},{"id":237110,"name":"Qianjin Lu","orcid":"0000-0002-7749-9618","position":9,"is_corresponding":false},{"id":256588,"name":"Nu Zhang","orcid":"0000-0001-9695-210X","position":10,"is_corresponding":false},{"id":314395,"name":"Shruti Mishra","orcid":"0000-0001-8055-1475","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T21:08:26.834549Z","pmid":"32991667","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}