{"doi":"10.1084/jem.20191453","title":"Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells","abstract":"Cytotoxic T cells play a key role in adaptive immunity by killing infected or cancerous cells. While the transcriptional control of CD8 T cell differentiation and effector function following T cell activation has been extensively studied, little is known about epigenetic regulation of these processes. Here we show that the histone deacetylase HDAC3 inhibits CD8 T cell cytotoxicity early during activation and is required for persistence of activated CD8 T cells following resolution of an acute infection. Mechanistically, HDAC3 inhibits gene programs associated with cytotoxicity and effector differentiation of CD8 T cells including genes encoding essential cytotoxicity proteins and key transcription factors. These data identify HDAC3 as an epigenetic regulator of the CD8 T cell cytotoxicity program.","journal":"The Journal of Experimental Medicine","year":2020,"id":59013,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":30773,"name":"Olamide Olawoyin","orcid":"0000-0002-9116-0557","position":1,"is_corresponding":false},{"id":227596,"name":"Paloma Cejas","orcid":"0000-0002-2090-7748","position":2,"is_corresponding":false},{"id":227594,"name":"Yingtian Xie","orcid":"0000-0003-0206-457X","position":3,"is_corresponding":false},{"id":43266,"name":"Clifford A. Meyer","orcid":"0000-0002-8321-2839","position":4,"is_corresponding":false},{"id":30763,"name":"Yoshinaga Ito","orcid":"0000-0002-5567-7014","position":5,"is_corresponding":false},{"id":282809,"name":"Qing Yu Weng","orcid":"0000-0002-4678-2664","position":6,"is_corresponding":false},{"id":69344,"name":"David E. Fisher","orcid":"0000-0002-5506-0575","position":7,"is_corresponding":false},{"id":227618,"name":"Henry W. Long","orcid":"0000-0001-6849-6629","position":8,"is_corresponding":false},{"id":443,"name":"Myles Brown","orcid":"0000-0002-8213-1658","position":9,"is_corresponding":false},{"id":310413,"name":"Hye‐Jung Kim","orcid":"0000-0003-1529-8930","position":10,"is_corresponding":false},{"id":24148,"name":"Kai W. Wucherpfennig","orcid":"0000-0002-1829-302X","position":11,"is_corresponding":false},{"id":91048,"name":"Rong En Tay","orcid":"0000-0003-3647-9271","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-18T21:07:59.189921Z","pmid":"32374402","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}