{"doi":"10.1084/jem.20191287","title":"Early T-bet promotes LFA1 upregulation required for CD8+ effector and memory T cell development","abstract":"The T-box transcription factor T-bet is regarded as a \"master regulator\" of CD4+ Th1 differentiation and IFN-γ production. However, in multiple models of infection, T-bet appears less critical for CD8+ T cell expansion and effector function. Here, we show that following vaccination with a replication-deficient strain of Toxoplasma gondii, CD8+ T cell expression of T-bet is required for optimal expansion of parasite-specific effector CD8+ T cells. Analysis of the early events associated with T cell activation reveals that the α chain of LFA1, CD11a, is a target of T-bet, and T-bet is necessary for CD8+ T cell upregulation of this integrin, which influences the initial priming of CD8+ effector T cells. We propose that the early expression of T-bet represents a T cell-intrinsic factor that optimizes T-DC interactions necessary to generate effector responses.","journal":"The Journal of Experimental Medicine","year":2022,"id":260455,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9469,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":563023,"name":"Anthony T. Phan","orcid":"0000-0003-2935-6070","position":1,"is_corresponding":false},{"id":563020,"name":"David A. Christian","orcid":"0000-0002-7160-9900","position":2,"is_corresponding":false},{"id":228866,"name":"Trevor J. Blain","orcid":"0000-0002-3415-1697","position":3,"is_corresponding":false},{"id":914153,"name":"Qun Fang","orcid":"0000-0002-1380-2868","position":4,"is_corresponding":false},{"id":244593,"name":"John L. Johnson","orcid":"0000-0003-3185-3201","position":5,"is_corresponding":false},{"id":313558,"name":"Nathan H. Roy","orcid":"0000-0003-1229-2808","position":6,"is_corresponding":false},{"id":563022,"name":"Lindsey A. Shallberg","orcid":"0000-0001-6573-7327","position":7,"is_corresponding":false},{"id":351178,"name":"Ross M. Kedl","orcid":"0000-0002-9065-7895","position":8,"is_corresponding":false},{"id":305888,"name":"Christopher A. Hunter","orcid":"0000-0003-3092-1428","position":9,"is_corresponding":false},{"id":914152,"name":"Gretchen Harms Pritchard","orcid":"0000-0002-7564-4906","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T00:26:07.666421Z","pmid":"36445307","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}