{"doi":"10.1084/jem.20190888","title":"Trib1 regulates T cell differentiation during chronic infection by restraining the effector program","abstract":"In chronic infections, the immune response fails to control virus, leading to persistent antigen stimulation and the progressive development of T cell exhaustion. T cell effector differentiation is poorly understood in the context of exhaustion, but targeting effector programs may provide new strategies for reinvigorating T cell function. We identified Tribbles pseudokinase 1 (Trib1) as a central regulator of antiviral T cell immunity, where loss of Trib1 led to a sustained enrichment of effector-like KLRG1+ T cells, enhanced function, and improved viral control. Single-cell profiling revealed that Trib1 restrains a population of KLRG1+ effector CD8 T cells that is transcriptionally distinct from exhausted cells. Mechanistically, we identified an interaction between Trib1 and the T cell receptor (TCR) signaling activator, MALT1, which disrupted MALT1 signaling complexes. These data identify Trib1 as a negative regulator of TCR signaling and downstream function, and reveal a link between Trib1 and effector versus exhausted T cell differentiation that can be targeted to improve antiviral immunity.","journal":"The Journal of Experimental Medicine","year":2020,"id":98365,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":340128,"name":"Sarah Stein","orcid":"0000-0002-1485-0829","position":1,"is_corresponding":false},{"id":36445,"name":"Makoto Kurachi","orcid":"0000-0002-7202-7822","position":2,"is_corresponding":false},{"id":326066,"name":"Jelena Petrovic","orcid":"0000-0002-5894-3568","position":3,"is_corresponding":false},{"id":324341,"name":"Gregory W. Schwartz","orcid":"0000-0003-4003-3045","position":4,"is_corresponding":false},{"id":485223,"name":"Ethan A. Mack","orcid":"0000-0002-4529-4917","position":5,"is_corresponding":false},{"id":485224,"name":"Sacha Uljon","orcid":"0000-0001-5190-6652","position":6,"is_corresponding":false},{"id":340838,"name":"Winona Wu","orcid":null,"position":7,"is_corresponding":false},{"id":485917,"name":"Anne G. DeHart","orcid":null,"position":8,"is_corresponding":false},{"id":485225,"name":"Susan McClory","orcid":"0000-0002-4607-5230","position":9,"is_corresponding":false},{"id":485226,"name":"Lanwei Xu","orcid":"0000-0003-1932-5799","position":10,"is_corresponding":false},{"id":325359,"name":"Phyllis A. Gimotty","orcid":"0000-0002-3850-9799","position":11,"is_corresponding":false},{"id":852,"name":"Stephen C. Blacklow","orcid":"0000-0002-6904-1981","position":12,"is_corresponding":false},{"id":324342,"name":"Robert B. Faryabi","orcid":"0000-0002-7931-2175","position":13,"is_corresponding":false},{"id":36451,"name":"E. John Wherry","orcid":"0000-0003-0477-1956","position":14,"is_corresponding":false},{"id":296325,"name":"Martha S. Jordan","orcid":"0000-0003-2359-3227","position":15,"is_corresponding":false},{"id":853,"name":"Warren S. Pear","orcid":"0000-0002-2624-0526","position":16,"is_corresponding":false},{"id":485222,"name":"Kelly Rome","orcid":"0000-0002-0703-1788","position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-18T22:36:34.157932Z","pmid":"32150623","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}