{"doi":"10.1084/jem.20190834","title":"A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans","abstract":"T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine fetal thymus by day 16 of ontogeny, underwent αβ TCR-mediated positive selection into CD4+ or CD8+ thymocytes, and constituted up to 10% of TCRδ+ cells in lymphoid organs. They expressed high levels of IL-1R1 and IL-23R and secreted IFN-γ, IL-17, and GM-CSF in response to canonically restricted peptide antigens or stimulation with IL-1β and IL-23. Hybrid αβ-γδ T cells were transcriptomically distinct from conventional γδ T cells and displayed a hyperinflammatory phenotype enriched for chemokine receptors and homing molecules that facilitate migration to sites of inflammation. These proinflammatory T cells promoted bacterial clearance after infection with Staphylococcus aureus and, by licensing encephalitogenic Th17 cells, played a key role in the development of autoimmune disease in the central nervous system.","journal":"The Journal of Experimental Medicine","year":2020,"id":66777,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9409,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":354841,"name":"Caroline E. 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Lalor","orcid":"0000-0003-0882-7152","position":10,"is_corresponding":false},{"id":353702,"name":"Julie C. Ribot","orcid":"0000-0002-7852-343X","position":11,"is_corresponding":false},{"id":353703,"name":"Song Baik","orcid":"0000-0003-4177-323X","position":12,"is_corresponding":false},{"id":353704,"name":"Barry Moran","orcid":"0000-0002-8243-1079","position":13,"is_corresponding":false},{"id":353705,"name":"Aoife McGinley","orcid":"0000-0003-1544-1514","position":14,"is_corresponding":false},{"id":353706,"name":"Valerie Pivorunas","orcid":"0000-0001-6647-8494","position":15,"is_corresponding":false},{"id":354843,"name":"L. 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