{"doi":"10.1084/jem.20190541","title":"Targeting leukocidin-mediated immune evasion protects mice from <i>Staphylococcus aureus</i> bacteremia","abstract":"Staphylococcus aureus is responsible for various diseases in humans, and recurrent infections are commonly observed. S. aureus produces an array of bicomponent pore-forming toxins that target and kill leukocytes, known collectively as the leukocidins. The contribution of these leukocidins to impair the development of anti-S. aureus adaptive immunity and facilitate reinfection is unclear. Using a murine model of recurrent bacteremia, we demonstrate that infection with a leukocidin mutant results in increased levels of anti-S. aureus antibodies compared with mice infected with the WT parental strain, indicating that leukocidins negatively impact the generation of anti-S. aureus antibodies in vivo. We hypothesized that neutralizing leukocidin-mediated immune subversion by vaccination may shift this host-pathogen interaction in favor of the host. Leukocidin-immunized mice produce potent leukocidin-neutralizing antibodies and robust Th1 and Th17 responses, which collectively protect against bloodstream infections. Altogether, these results demonstrate that blocking leukocidin-mediated immune evasion can promote host protection against S. aureus bloodstream infection.","journal":"The Journal of Experimental Medicine","year":2020,"id":96581,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":478774,"name":"Keenan A. Lacey","orcid":"0000-0002-9242-0170","position":1,"is_corresponding":false},{"id":253551,"name":"Joseph C. Devlin","orcid":"0000-0002-0003-4812","position":2,"is_corresponding":false},{"id":479964,"name":"Maryaline Coffre","orcid":null,"position":3,"is_corresponding":false},{"id":479965,"name":"Alexis G. Sommerfield","orcid":null,"position":4,"is_corresponding":false},{"id":478775,"name":"Rita Chan","orcid":"0000-0001-7521-9507","position":5,"is_corresponding":false},{"id":478776,"name":"Aidan O’Malley","orcid":"0000-0002-0544-7421","position":6,"is_corresponding":false},{"id":75652,"name":"Sergei B. Koralov","orcid":"0000-0002-4843-3791","position":7,"is_corresponding":false},{"id":253555,"name":"P’ng Loke","orcid":"0000-0002-6211-3292","position":8,"is_corresponding":false},{"id":308670,"name":"Victor J. Torres","orcid":"0000-0002-7126-0489","position":9,"is_corresponding":false},{"id":447492,"name":"Kayan Tam","orcid":"0000-0003-0534-1691","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T22:35:06.014648Z","pmid":"32602902","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}