{"doi":"10.1084/jem.20182163","title":"Human <i>KIT</i>+ myeloid cells facilitate visceral metastasis by melanoma","abstract":"Metastasis of melanoma significantly worsens prognosis; thus, therapeutic interventions that prevent metastasis could improve patient outcomes. Here, we show using humanized mice that colonization of distant visceral organs with melanoma is dependent upon a human CD33+CD11b+CD117+ progenitor cell subset comprising <4% of the human CD45+ leukocytes. Metastatic tumor-infiltrating CD33+ cells from patients and humanized (h)NSG-SGM3 mice showed converging transcriptional profiles. Single-cell RNA-seq analysis identified a gene signature of a KIT/CD117-expressing CD33+ subset that correlated with decreased overall survival in a TCGA melanoma cohort. Thus, human CD33+CD11b+CD117+ myeloid cells represent a novel candidate biomarker as well as a therapeutic target for metastatic melanoma.","journal":"The Journal of Experimental Medicine","year":2021,"id":199938,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9502,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":777019,"name":"Jan Martínek","orcid":"0000-0001-5277-8859","position":1,"is_corresponding":false},{"id":777020,"name":"Te-Chia Wu","orcid":"0000-0001-8302-3985","position":2,"is_corresponding":false},{"id":777021,"name":"Kyung In Kim","orcid":"0000-0002-4822-8333","position":3,"is_corresponding":false},{"id":13481,"name":"Joshy George","orcid":"0000-0001-8510-8229","position":4,"is_corresponding":false},{"id":777022,"name":"Elaheh Ahmadzadeh","orcid":"0000-0002-1358-6480","position":5,"is_corresponding":false},{"id":777625,"name":"Rick Maser","orcid":null,"position":6,"is_corresponding":false},{"id":777023,"name":"Florentina Marches","orcid":"0000-0002-5775-9101","position":7,"is_corresponding":false},{"id":711829,"name":"Patrick Metang","orcid":"0000-0002-2244-0213","position":8,"is_corresponding":false},{"id":777024,"name":"Pierre Authié","orcid":"0000-0002-8293-3239","position":9,"is_corresponding":false},{"id":777025,"name":"Vanessa K.P. Oliveira","orcid":"0000-0002-1098-7924","position":10,"is_corresponding":false},{"id":777026,"name":"Victor G. Wang","orcid":"0000-0002-2427-6189","position":11,"is_corresponding":false},{"id":245984,"name":"Jeffrey H. Chuang","orcid":"0000-0002-3298-2358","position":12,"is_corresponding":false},{"id":295946,"name":"Paul Robson","orcid":"0000-0002-0191-3958","position":13,"is_corresponding":false},{"id":55820,"name":"Jacques Banchereau","orcid":"0000-0003-3535-7221","position":14,"is_corresponding":false},{"id":646421,"name":"Karolina Palucka","orcid":"0000-0002-1600-6066","position":15,"is_corresponding":false},{"id":777018,"name":"Chun I. Yu","orcid":"0000-0002-4304-2177","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T23:50:44.479665Z","pmid":"33857287","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}