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As the PU.1–IRF8 complex functions in a reciprocal manner to IRF4, we propose that concentration-dependent competition between these factors controls B cell terminal differentiation.</jats:p>","journal":"Journal of Experimental Medicine","year":2014,"id":608741,"datarank":0.7525919755222388,"base_score":5.017279836814924,"endowment":5.017279836814924,"self_citation_contribution":0.7525919755222388,"citation_network_contribution":0.0,"self_endowment_contribution":0.7525919755222388,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":150,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1563756,"name":"Simon N. 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The distinct transcriptomes of B cells and plasma cells are maintained by the antagonistic influences of two groups of transcription factors: those that maintain the B cell program, including BCL6 and PAX5, and plasma cell–promoting factors, such as IRF4 and BLIMP-1. We show that the complex of IRF8 and PU.1 controls the propensity of B cells to undergo CSR and plasma cell differentiation by concurrently promoting the expression of BCL6 and PAX5 and repressing AID and BLIMP-1. As the PU.1–IRF8 complex functions in a reciprocal manner to IRF4, we propose that concentration-dependent competition between these factors controls B cell terminal differentiation.</jats:p>","is_dataset_classified":null,"base_score":5.017279836814924,"endowment":5.017279836814924,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25288399","pmcid":"PMC4203955","openalex_id":"https://openalex.org/W2126938417","authors":[],"funders":[{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"1054925","title":"A Systems Approach to the Adaptive Immune Response"},{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"575500","title":"The Regulation of Antibody: A Systems Approach"}],"total_grants":2,"fwci":5.2202,"citation_percentile":0.9666385,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":12},{"year":2016,"count":15},{"year":2017,"count":15},{"year":2018,"count":14},{"year":2019,"count":11},{"year":2020,"count":22},{"year":2021,"count":14},{"year":2022,"count":12},{"year":2023,"count":6},{"year":2024,"count":13},{"year":2025,"count":9},{"year":2026,"count":6}],"oa_status":"hybrid","license":"cc-by-nc-sa","oa_locations":[{"url":"https://rupress.org/jem/article-pdf/211/11/2169/1212117/jem_20140425.pdf","host_type":"journal"},{"url":"https://rupress.org/jem/article-pdf/211/11/2169/1212117/jem_20140425.pdf","host_type":"publisher"},{"url":"https://rupress.org/jem/article-pdf/211/11/2169/1748365/jem_20140425.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1084/jem.20140425","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25288399","host_type":"repository"},{"url":"http://hdl.handle.net/11343/262940","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4203955","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4203955","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4203955?pdf=render","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/pmc4203955?pdf=render","host_type":""},{"url":"http://dx.doi.org/10.1084/jem.20140425","host_type":""},{"url":"https://dx.doi.org/10.1084/jem.20140425","host_type":""},{"url":"https://doi.org/https://doi.org/10.1084/jem.20140425","host_type":""}],"fields_of_study":["T-cell and B-cell Immunology","Immune Cell Function and Interaction","Cytomegalovirus and herpesvirus research","0301 basic medicine","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Interferon Regulatory Factor-8","Interferon Regulatory Factor-4","Proto-Oncogene Protein Spi-1","Animals","Cell Differentiation","Cell Line","Gene Expression Regulation","Humans","Mice, Transgenic","Plasma Cells","Protein Binding","Proto-Oncogene Proteins","Trans-Activators","Cluster Analysis","Immunoglobulin Class Switching","Gene Expression Profiling","Interferon Regulatory Factors","Mice"],"keywords":["BCL6","IRF4","IRF8","PAX5","Transcription factor","B cell","Biology","Plasma cell","Cellular differentiation","Antibody","Cell biology","Molecular biology","Immunology","Gene","Genetics","Germinal center","Interferon Regulatory Factor-8","Plasma Cells","610","Mice, Transgenic","Article","Cell Line","Mice","Proto-Oncogene Proteins","Animals","Cluster Analysis","Humans","Gene Expression Profiling","Proto-Oncogene Protein Spi-1","Cell Differentiation","Immunoglobulin Class Switching","Gene Expression Regulation","Interferon Regulatory Factors","Trans-Activators","Interferon Regulatory Factor-4","Protein Binding"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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