{"doi":"10.1084/jem.186.8.1357","title":"Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice","abstract":"To determine the role of CD11/CD18 complexes in neutrophil emigration, inflammation was induced in the skin, lungs, or peritoneum of mutant mice deficient in CD18 (CD18-/- mutants). Peripheral blood of CD18-/- mutants contained 11-fold more neutrophils than did blood of wild-type (WT) mice. During irritant dermatitis induced by topical application of croton oil, the number of emigrated neutrophils in histological sections of dermis was 98% less in CD18-/- mutants than in WT mice. During Streptococcus pneumoniae pneumonia, neutrophil emigration in CD18-/- mutants was not reduced. These data are consistent with expectations based on studies using blocking antibodies to inhibit CD11/CD18 complexes, and on observations of humans lacking CD11/CD18 complexes. The number of emigrated neutrophils in lung sections during Escherichia coli pneumonia, or in peritoneal lavage fluid after 4 h of S. pneumoniae peritonitis, was not reduced in CD18-/- mutants, but rather was greater than the WT values (240 +/- 30 and 220 +/- 30% WT, respectively). Also, there was no inhibition of neutrophil emigration during sterile peritonitis induced by intraperitoneal injection of thioglycollate (90 +/- 20% WT). These data contrast with expectations. Whereas CD11/CD18 complexes are essential to the dermal emigration of neutrophils during acute dermatitis, CD18-/- mutant mice demonstrate surprising alternative pathways for neutrophil emigration during pneumonia or peritonitis.","journal":"The Journal of Experimental Medicine","year":1997,"id":11144,"datarank":1.3305994506609033,"base_score":8.87066300440602,"endowment":8.87066300440602,"self_citation_contribution":1.3305994506609033,"citation_network_contribution":0.0,"self_endowment_contribution":1.3305994506609033,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7119,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0429,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"1997-10-20","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":89955,"name":"Hiroshi Kubo","orcid":"0000-0001-6097-4542","position":1,"is_corresponding":false},{"id":89956,"name":"Gregory J. Kutkoski","orcid":null,"position":2,"is_corresponding":false},{"id":89957,"name":"Sabrina D. Bhagwan","orcid":null,"position":3,"is_corresponding":false},{"id":89958,"name":"Karin Scharffetter-Kochanek","orcid":null,"position":4,"is_corresponding":false},{"id":89959,"name":"Arthur L. Beaudet","orcid":"0000-0003-2083-3192","position":5,"is_corresponding":false},{"id":89960,"name":"Claire M. Doerschuk","orcid":"0000-0003-2638-3321","position":6,"is_corresponding":false},{"id":89961,"name":"G. J. Kutkoski","orcid":null,"position":7,"is_corresponding":false},{"id":89962,"name":"Karin Scharffetter‐­Kochanek","orcid":"0000-0002-9655-685X","position":8,"is_corresponding":false},{"id":89954,"name":"Joseph P. Mizgerd","orcid":"0000-0002-4042-3169","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}