{"doi":"10.1084/jem.179.5.1677","title":"Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor.","abstract":"<jats:p>Previous attempts at identifying the constitutive source(s) of granulocyte colony-stimulating factor (G-CSF) in human bone marrow have been unsuccessful despite the fact that normal bone marrow supports abundant myelopoiesis in vivo. We hypothesized that the intimate physical association between bone and hematopoietic cells facilitates interactions between osteoblasts and hematopoietic stem cells. Here we provide the first direct evidence that human osteoblasts participate in hematopoiesis by constitutively producing G-CSF and present the protein in a membrane-associated fashion to human hematopoietic progenitors. These results suggest a direct and central role for osteoblasts in normal myelopoiesis.</jats:p>","journal":"The Journal of experimental medicine","year":1994,"id":597035,"datarank":0.9002122316941727,"base_score":6.0014148779611505,"endowment":6.0014148779611505,"self_citation_contribution":0.9002122316941727,"citation_network_contribution":0.0,"self_endowment_contribution":0.9002122316941727,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":403,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1529311,"name":"S G Emerson","orcid":null,"position":1,"is_corresponding":false},{"id":1529309,"name":"R S Taichman","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor.","abstract":"<jats:p>Previous attempts at identifying the constitutive source(s) of granulocyte colony-stimulating factor (G-CSF) in human bone marrow have been unsuccessful despite the fact that normal bone marrow supports abundant myelopoiesis in vivo. We hypothesized that the intimate physical association between bone and hematopoietic cells facilitates interactions between osteoblasts and hematopoietic stem cells. Here we provide the first direct evidence that human osteoblasts participate in hematopoiesis by constitutively producing G-CSF and present the protein in a membrane-associated fashion to human hematopoietic progenitors. These results suggest a direct and central role for osteoblasts in normal myelopoiesis.</jats:p>","is_dataset_classified":null,"base_score":6.0014148779611505,"endowment":6.0014148779611505,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7513014","pmcid":"PMC2191506","openalex_id":"https://openalex.org/W2156505612","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL-48896","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P01 CA-49639","title":null}],"total_grants":2,"fwci":1.9111,"citation_percentile":0.86564589,"influential_citations":0,"citation_trend":[{"year":2012,"count":23},{"year":2013,"count":25},{"year":2014,"count":22},{"year":2015,"count":21},{"year":2016,"count":24},{"year":2017,"count":26},{"year":2018,"count":15},{"year":2019,"count":9},{"year":2020,"count":19},{"year":2021,"count":15},{"year":2022,"count":12},{"year":2023,"count":7},{"year":2024,"count":12},{"year":2025,"count":6},{"year":2026,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://rupress.org/jem/article-pdf/179/5/1677/1105006/1677.pdf","host_type":"journal"},{"url":"https://rupress.org/jem/article-pdf/179/5/1677/1105006/1677.pdf","host_type":"publisher"},{"url":"https://rupress.org/jem/article-pdf/179/5/1677/1675784/1677.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1084/jem.179.5.1677","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7513014","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2191506","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC2191506","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC2191506?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Bone Metabolism and Diseases","Mesenchymal stem cell research","Bone and Joint Diseases","Base Sequence","DNA Primers","Granulocyte Colony-Stimulating Factor","Hematopoiesis","Humans","Immunohistochemistry","In Vitro Techniques","Molecular Sequence Data","Osteoblasts","Polymerase Chain Reaction"],"mesh_terms":["Base Sequence","Hematopoiesis","Humans","Immunohistochemistry","Molecular Sequence Data","Osteoblasts","Polymerase Chain Reaction","Granulocyte Colony-Stimulating Factor","DNA Primers","In Vitro Techniques"],"keywords":["Myelopoiesis","Haematopoiesis","Granulocyte","Bone marrow","Granulocyte colony-stimulating factor","Progenitor cell","Stem cell","Biology","Cell biology","Hematopoietic growth factor","Stem cell factor","Immunology","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T12:02:09.338399Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}