{"doi":"10.1084/jem.176.1.293","title":"In vivo cellular tropism of human T cell leukemia virus type II (HTLV-II).","abstract":"<jats:p>To investigate the in vivo cellular tropism of human T cell leukemia virus type II (HTLV-II), subpopulations of fresh peripheral blood mononuclear cells from infected individuals were isolated and analyzed by polymerase chain reaction for the presence of provirus. In eight of nine patients, HTLV-II was detected exclusively in the CD8+ T lymphocyte population. In the remaining patient, provirus was also detected in CD4+ T lymphocytes. Provirus was not detected in B lymphocytes or monocytes of any patient. These results suggest that in vivo HTLV-II has a preferential, and perhaps in some cases, an exclusive tropism for CD8+ T lymphocytes. The findings contrast sharply with those on HTLV-I where there is a preferential tropism for CD4+ T lymphocytes. Although HTLV-II infection has not been consistently associated with any lymphoproliferative disorders, the results suggest that if these occur, they may be different from those known to be associated with HTLV-I.</jats:p>","journal":"The Journal of experimental medicine","year":1992,"id":619887,"datarank":0.7117398192544876,"base_score":4.74493212836325,"endowment":4.74493212836325,"self_citation_contribution":0.7117398192544876,"citation_network_contribution":0.0,"self_endowment_contribution":0.7117398192544876,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":114,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1599944,"name":"M B Ramundo","orcid":null,"position":1,"is_corresponding":false},{"id":1599945,"name":"H Takahashi","orcid":null,"position":2,"is_corresponding":false},{"id":1576227,"name":"W W Hall","orcid":null,"position":3,"is_corresponding":false},{"id":1599943,"name":"S Ijichi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"In vivo cellular tropism of human T cell leukemia virus type II (HTLV-II).","abstract":"<jats:p>To investigate the in vivo cellular tropism of human T cell leukemia virus type II (HTLV-II), subpopulations of fresh peripheral blood mononuclear cells from infected individuals were isolated and analyzed by polymerase chain reaction for the presence of provirus. In eight of nine patients, HTLV-II was detected exclusively in the CD8+ T lymphocyte population. In the remaining patient, provirus was also detected in CD4+ T lymphocytes. Provirus was not detected in B lymphocytes or monocytes of any patient. These results suggest that in vivo HTLV-II has a preferential, and perhaps in some cases, an exclusive tropism for CD8+ T lymphocytes. The findings contrast sharply with those on HTLV-I where there is a preferential tropism for CD4+ T lymphocytes. Although HTLV-II infection has not been consistently associated with any lymphoproliferative disorders, the results suggest that if these occur, they may be different from those known to be associated with HTLV-I.</jats:p>","is_dataset_classified":null,"base_score":4.74493212836325,"endowment":4.74493212836325,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1351922","pmcid":"PMC2119301","openalex_id":"https://openalex.org/W2150908206","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"CA5 1012-01A1","title":null}],"total_grants":1,"fwci":3.1048,"citation_percentile":0.92937622,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":1},{"year":2014,"count":5},{"year":2015,"count":2},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":3},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":5},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://rupress.org/jem/article-pdf/176/1/293/1102661/293.pdf","host_type":"journal"},{"url":"https://rupress.org/jem/article-pdf/176/1/293/1102661/293.pdf","host_type":"publisher"},{"url":"https://rupress.org/jem/article-pdf/176/1/293/1673327/293.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1084/jem.176.1.293","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1351922","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2119301","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC2119301","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC2119301?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["T-cell and Retrovirus Studies","Animal Disease Management and Epidemiology","Vector-Borne Animal Diseases","Adult","Base Sequence","CD4-Positive T-Lymphocytes","CD8 Antigens","Female","Human T-lymphotropic virus 2","Humans","Lymphoproliferative Disorders","Male","Middle Aged","Molecular Sequence Data","Polymerase Chain Reaction","Proviruses","T-Lymphocytes"],"mesh_terms":["Adult","Base Sequence","Female","Humans","Lymphoproliferative Disorders","Male","Middle Aged","Molecular Sequence Data","Proviruses","T-Lymphocytes","Human T-lymphotropic virus 2","CD4-Positive T-Lymphocytes","Polymerase Chain Reaction","CD8 Antigens"],"keywords":["Provirus","Tropism","Virology","Biology","CD8","Human T-lymphotropic virus 1","Leukemia","Tissue tropism","Peripheral blood mononuclear cell","Virus","Population","Immunology","Human T-lymphotropic virus","T-cell leukemia","Antigen","In vitro","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T09:02:53.185964Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}