{"doi":"10.1083/jcb.202507134","title":"Two δ-catenins, plakophilin 4 and p120, promote formation of distinct types of adherens junctions","abstract":"Classical cadherins are instrumental for connecting cells into tissues by forming adherens junctions (AJs), a structurally diverse class of cell-cell adhesions tailored to specific membrane domains, cell types, and particular functions. The mechanisms that underlie the AJ diversification remain unknown. Here, we show that two δ-catenin family members, p120 and plakophilin 4 (pkp4), which bind the intracellular region of classical cadherins, promote distinct modes of cadherin clustering, thereby contributing to AJ specialization. The mode promoted by p120 is driven by interactions between cadherin-associated protein, α-catenin, and actin filaments. This \"canonical\" clustering mechanism generates apical and basal AJs that play a major role in overall cell-cell adhesion. The mode promoted by pkp4 is driven by an α-catenin-independent mechanism. It generates lateral AJs, which apparently function in processes other than cell-cell adhesion. Collectively, our findings show that δ-catenins regulate the balance between different AJ assembly pathways, thereby contributing to AJ diversification.","journal":"The Journal of Cell Biology","year":2025,"id":587898,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":478289,"name":"Regina B. Troyanovsky","orcid":null,"position":1,"is_corresponding":false},{"id":395607,"name":"Farida Korobova","orcid":"0000-0002-1395-0430","position":2,"is_corresponding":false},{"id":477581,"name":"Sergey M. Troyanovsky","orcid":"0000-0001-7368-9708","position":3,"is_corresponding":false},{"id":477580,"name":"Indrajyoti Indra","orcid":"0000-0001-5381-7397","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:59:43.096742Z","pmid":"41746206","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}