{"doi":"10.1083/jcb.202502087","title":"Anaphase onset requires CKS-1–mediated destruction of securin in meiosis I and cyclin B1 in meiosis II","abstract":"The cyclin-dependent kinase subunit CKS remains poorly understood. We found that Caenorhabditis elegans CKS-1 and its partner CDK-1 co-localized to the cytosol, chromosomes, and spindle structures throughout cell division. Nevertheless, CKS-1 was required well after CDK-1, during oocyte meiosis I metaphase, which was prolonged in cks-1 mutants. Anaphase A precedes anaphase B in C. elegans oocytes, and while delayed in onset, chromosomes in cks-1 mutants separated normally during meiosis I anaphase A but failed to separate further and instead rapidly transitioned into meiosis II prometaphase, skipping anaphase B. The anaphase A to B transition also was defective during meiosis II. Furthermore, meiosis I anaphase B required that CKS-1 be bound to CDK-1 and have a functional anion pocket. Finally, our results suggest that CKS-1 promotes anaphase onset during meiosis I through securin destruction and during meiosis II through cyclin B1 destruction, and that both securin and cyclin B3 have positive roles independent of their destruction during meiosis II.","journal":"The Journal of Cell Biology","year":2025,"id":554579,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9494,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1012591,"name":"Eisuke Sumiyoshi","orcid":"0000-0001-7336-6095","position":1,"is_corresponding":false},{"id":378241,"name":"Bruce Bowerman","orcid":"0000-0002-6479-8707","position":2,"is_corresponding":false},{"id":1451894,"name":"Jie Yang","orcid":"0009-0008-5487-4439","position":0,"is_corresponding":true}],"reference_count":136,"raw_metadata":null,"created_at":"2026-07-19T02:54:50.112989Z","pmid":"41569111","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}