{"doi":"10.1083/jcb.202411034","title":"CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization","abstract":"The ER relies on the microtubule cytoskeleton for the organization of its extended membrane network, but how microtubule-based motors contribute remains unclear. Using biochemical and cell-based assays, we identify cerebellar degeneration-related protein 2 (CDR2) and its paralog CDR2-like (CDR2L), onconeural antigens with poorly understood functions, as ER adaptors for cytoplasmic dynein-1 (dynein). We demonstrate in human cancer cells that CDR2 is recruited by the integral ER membrane protein kinectin (KTN1) and that double knockout of CDR2 and CDR2L enhances KTN1-dependent ER sheet stacking, reversal of which by exogenous CDR2 requires its dynein-binding CC1 box motif. Exogenous CDR2 expression additionally promotes CC1 box-dependent clustering of ER sheets near centrosomes. CDR2 competes with the eEF1Bβ subunit of translation elongation factor 1 for binding to KTN1, and eEF1Bβ knockdown increases endogenous CDR2 levels on ER sheets, inducing their centrosome-proximal clustering. Our study describes a novel molecular pathway that implicates dynein in ER sheet organization and may be involved in the pathogenesis of paraneoplastic cerebellar degeneration.","journal":"The Journal of Cell Biology","year":2025,"id":514813,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9602,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1378181,"name":"Kashish Singh","orcid":"0000-0002-9891-8148","position":1,"is_corresponding":false},{"id":862038,"name":"José B. Gama","orcid":"0000-0002-7011-1502","position":2,"is_corresponding":false},{"id":1378182,"name":"M. V. B. Moreira","orcid":"0000-0001-8544-6770","position":3,"is_corresponding":false},{"id":862037,"name":"Ricardo Celestino","orcid":"0000-0002-9605-6433","position":4,"is_corresponding":false},{"id":201937,"name":"Ana X. Carvalho","orcid":"0000-0002-2256-7134","position":5,"is_corresponding":false},{"id":1378183,"name":"Paulo S. Pereira","orcid":"0000-0001-9812-8034","position":6,"is_corresponding":false},{"id":686842,"name":"Carla M. C. Abreu","orcid":"0000-0002-8070-8388","position":7,"is_corresponding":false},{"id":305210,"name":"Tiago J. Dantas","orcid":"0000-0002-0120-4895","position":8,"is_corresponding":false},{"id":1176853,"name":"Andrew P. Carter","orcid":"0000-0001-7292-5430","position":9,"is_corresponding":false},{"id":598720,"name":"Reto Gassmann","orcid":"0000-0002-0360-2977","position":10,"is_corresponding":false},{"id":825745,"name":"Vanessa Teixeira","orcid":"0000-0003-1971-1999","position":0,"is_corresponding":true}],"reference_count":96,"raw_metadata":null,"created_at":"2026-07-19T02:48:34.431522Z","pmid":"40637585","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}