{"doi":"10.1083/jcb.202409057","title":"Importin-9 and a TPR domain protein MpH drive periodic patterning of ciliary arrays in <i>Tetrahymena</i>","abstract":"We explored how the number of structures is determined in an intracellular organelle series. In Tetrahymena, the oral apparatus contains three diagonal ciliary rows: M1, M2, and M3. During development, the M rows emerge by sequential segmentation of a group of basal bodies, starting with the longest and most anterior M1 and ending with the shortest and most posterior M3. The mpD-1 and mpH-1 alleles increase and decrease the number of M rows, respectively. We identify MpH as a TPR protein and MpD as an importin-9. Both proteins localize to the M rows and form concentration gradients. MpH is a row elongation factor whose loss shortens all M rows and often prevents the formation of M3. MpD limits row initiation after the emergence of M2. MpD could be a part of a negative feedback loop that limits row initiation when M1 assembly is properly advanced. We conclude that the forming oral apparatus has properties of a semi-autonomous intracellular developmental field.","journal":"The Journal of Cell Biology","year":2025,"id":563463,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":383851,"name":"Wolfgang Maier","orcid":"0000-0002-9464-6640","position":1,"is_corresponding":false},{"id":1046687,"name":"Mireya Parra","orcid":"0009-0002-2025-6372","position":2,"is_corresponding":false},{"id":1466174,"name":"Elise McCollough Nanista","orcid":"0009-0002-3844-876X","position":3,"is_corresponding":false},{"id":1466538,"name":"Deborah Oluwabukola Sowunmi","orcid":null,"position":4,"is_corresponding":false},{"id":1466539,"name":"M. A. B. Hassan","orcid":null,"position":5,"is_corresponding":false},{"id":502526,"name":"Nathan Michael Chasen","orcid":"0000-0003-3346-9780","position":6,"is_corresponding":false},{"id":1466175,"name":"Sunita Sharma","orcid":"0000-0002-6531-7522","position":7,"is_corresponding":false},{"id":309347,"name":"Karl F. Lechtreck","orcid":"0000-0002-6219-6470","position":8,"is_corresponding":false},{"id":900585,"name":"Eric S. Cole","orcid":"0000-0002-0438-0165","position":9,"is_corresponding":false},{"id":467121,"name":"Natália E. Bernardes","orcid":"0000-0002-6498-0429","position":10,"is_corresponding":false},{"id":345462,"name":"Yuh Min Chook","orcid":"0000-0002-4974-0726","position":11,"is_corresponding":false},{"id":383855,"name":"Jacek Gaertig","orcid":"0000-0003-4420-4630","position":12,"is_corresponding":false},{"id":1466537,"name":"Anushi Suwaneththiya Deraniyagala","orcid":null,"position":0,"is_corresponding":true}],"reference_count":93,"raw_metadata":null,"created_at":"2026-07-19T02:56:13.374766Z","pmid":"40152790","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}