{"doi":"10.1083/jcb.202408155","title":"The PAX3-FOXO1 fusion gene reduces cell–ECM interactions and TGFβ signaling in rhabdomyosarcoma","abstract":"We identify downregulation of genes related to cell-ECM interactions and TGFβ signaling in FPRMS. We confirm that TGFβ signaling enhances cell-ECM interactions in FNRMS, utilizing confocal reflection microscopy to assess ECM remodeling, and a live-cell sensor to quantitatively assess TGFβ signaling. We also show that PAX3-FOXO1 increases NOS1 expression, stimulating nitric oxide synthesis, which inhibits TGFβ signaling and reduces cell-ECM interactions. We suggest that PAX3-FOXO1 reprograms ECM anchorage dependence by suppressing cell-ECM interactions. The fusion gene can determine sensitivity to growth inhibition via targeted disruption of cell-ECM interactions or TGFβ signaling. Reduced anchorage reliance by the gene may allow cells to survive in circulation and enhance FPRMS metastatic potential.","journal":"The Journal of Cell Biology","year":2025,"id":534014,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":228978,"name":"Ivan Chavez","orcid":"0000-0002-4840-9310","position":1,"is_corresponding":false},{"id":1416184,"name":"Vemula Chandra Kaladhar","orcid":"0000-0001-6714-2829","position":2,"is_corresponding":false},{"id":763356,"name":"Nikhil Mittal","orcid":"0000-0001-8499-7749","position":3,"is_corresponding":false},{"id":399494,"name":"Vic Zamloot","orcid":"0000-0003-0116-232X","position":4,"is_corresponding":false},{"id":1056523,"name":"Yuanzhong Pan","orcid":"0000-0002-6642-758X","position":5,"is_corresponding":false},{"id":437660,"name":"Sangyoon J. Han","orcid":"0000-0002-1384-665X","position":6,"is_corresponding":false},{"id":1416185,"name":"JinSeok Park","orcid":"0000-0001-6930-895X","position":7,"is_corresponding":false},{"id":1226339,"name":"Antonios Chronopoulos","orcid":"0000-0001-8752-5026","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-19T02:51:43.451278Z","pmid":"40586712","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}