{"doi":"10.1083/jcb.202312091","title":"Mmp14-dependent remodeling of the pericellular–dermal collagen interface governs fibroblast survival","abstract":"Dermal fibroblasts deposit type I collagen, the dominant extracellular matrix molecule found in skin, during early postnatal development. Coincident with this biosynthetic program, fibroblasts proteolytically remodel pericellular collagen fibrils by mobilizing the membrane-anchored matrix metalloproteinase, Mmp14. Unexpectedly, dermal fibroblasts in Mmp14-/- mice commit to a large-scale apoptotic program that leaves skin tissues replete with dying cells. A requirement for Mmp14 in dermal fibroblast survival is recapitulated in vitro when cells are embedded within, but not cultured atop, three-dimensional hydrogels of crosslinked type I collagen. In the absence of Mmp14-dependent pericellular proteolysis, dermal fibroblasts fail to trigger β1 integrin activation and instead actuate a TGF-β1/phospho-JNK stress response that leads to apoptotic cell death in vitro as well as in vivo. Taken together, these studies identify Mmp14 as a requisite cell survival factor that maintains dermal fibroblast viability in postnatal dermal tissues.","journal":"The Journal of Cell Biology","year":2024,"id":440743,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1072996,"name":"Xiao-Yan Li","orcid":"0000-0002-8776-6732","position":1,"is_corresponding":false},{"id":411310,"name":"Adam W. Olson","orcid":"0000-0003-3118-0393","position":2,"is_corresponding":false},{"id":500645,"name":"Elliot L. Botvinick","orcid":"0000-0001-9837-805X","position":3,"is_corresponding":false},{"id":1253208,"name":"Abhishek Kurup","orcid":null,"position":4,"is_corresponding":false},{"id":266165,"name":"Luis E. Gimenez","orcid":"0000-0002-0110-2135","position":5,"is_corresponding":false},{"id":253954,"name":"Jung‐Sun Cho","orcid":"0000-0001-7287-5760","position":6,"is_corresponding":false},{"id":253956,"name":"Stephen J. Weiss","orcid":"0000-0002-1864-6075","position":7,"is_corresponding":false},{"id":1252704,"name":"Farideh Sabeh","orcid":"0000-0002-8981-0389","position":0,"is_corresponding":true}],"reference_count":106,"raw_metadata":null,"created_at":"2026-07-19T02:01:01.842286Z","pmid":"38990714","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}