{"doi":"10.1083/jcb.202202060","title":"STING controls energy stress-induced autophagy and energy metabolism via STX17","abstract":"The stimulator of interferon genes (STING) plays a critical role in innate immunity. Emerging evidence suggests that STING is important for DNA or cGAMP-induced non-canonical autophagy, which is independent of a large part of canonical autophagy machineries. Here, we report that, in the absence of STING, energy stress-induced autophagy is upregulated rather than downregulated. Depletion of STING in Drosophila fat cells enhances basal- and starvation-induced autophagic flux. During acute exercise, STING knockout mice show increased autophagy flux, exercise endurance, and altered glucose metabolism. Mechanistically, these observations could be explained by the STING-STX17 interaction. STING physically interacts with STX17, a SNARE that is essential for autophagosome biogenesis and autophagosome-lysosome fusion. Energy crisis and TBK1-mediated phosphorylation both disrupt the STING-STX17 interaction, allow different pools of STX17 to translocate to phagophores and mature autophagosomes, and promote autophagic flux. Taken together, we demonstrate a heretofore unexpected function of STING in energy stress-induced autophagy through spatial regulation of autophagic SNARE STX17.","journal":"The Journal of Cell Biology","year":2022,"id":236957,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":64,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":858102,"name":"Shen Zhang","orcid":"0000-0003-4682-4470","position":1,"is_corresponding":false},{"id":501745,"name":"Nilay Nandi","orcid":"0000-0002-7088-4943","position":2,"is_corresponding":false},{"id":858103,"name":"Zhe Wu","orcid":"0000-0003-3474-8466","position":3,"is_corresponding":false},{"id":606840,"name":"Linsen Li","orcid":"0000-0002-1105-9070","position":4,"is_corresponding":false},{"id":350013,"name":"Yang Liu","orcid":"0000-0002-4428-3562","position":5,"is_corresponding":false},{"id":858558,"name":"Yuehan Wei","orcid":null,"position":6,"is_corresponding":false},{"id":858104,"name":"Yuan Zhao","orcid":"0000-0001-8553-8114","position":7,"is_corresponding":false},{"id":858105,"name":"Weigang Yuan","orcid":"0000-0002-9588-1415","position":8,"is_corresponding":false},{"id":858106,"name":"Chuchu Zhou","orcid":"0009-0004-7511-8107","position":9,"is_corresponding":false},{"id":808272,"name":"Guanghua Xiao","orcid":"0000-0002-6738-7014","position":10,"is_corresponding":false},{"id":49719,"name":"Beth Levine","orcid":"0000-0002-1460-1638","position":11,"is_corresponding":false},{"id":230829,"name":"Nan Yan","orcid":"0000-0002-0637-3989","position":12,"is_corresponding":false},{"id":620077,"name":"Shan Mou","orcid":"0000-0003-4160-1681","position":13,"is_corresponding":false},{"id":858559,"name":"Liufu Deng","orcid":null,"position":14,"is_corresponding":false},{"id":590302,"name":"Zaiming Tang","orcid":"0000-0001-9843-8788","position":15,"is_corresponding":false},{"id":858107,"name":"Xiaoxia Liu","orcid":"0000-0002-1333-9068","position":16,"is_corresponding":false},{"id":501747,"name":"Helmut Krämer","orcid":"0000-0002-1167-2676","position":17,"is_corresponding":false},{"id":392851,"name":"Qing Zhong","orcid":"0000-0001-6979-955X","position":18,"is_corresponding":false},{"id":858101,"name":"Yueguang Rong","orcid":"0000-0001-6661-9664","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T00:22:03.686498Z","pmid":"35510944","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}