{"doi":"10.1083/jcb.202201050","title":"Loss of ARL13 impedes BBSome-dependent cargo export from <i>Chlamydomonas</i> cilia","abstract":"The GTPase Arl13b participates in ciliary protein transport, but its contribution to intraflagellar transport (IFT), the main motor-based protein shuttle of cilia, remains largely unknown. Chlamydomonas arl13 mutant cilia were characterized by both abnormal reduction and accumulation of select membrane-associated proteins. With respect to the latter, a similar set of proteins including phospholipase D (PLD) also accumulated in BBSome-deficient cilia. IFT and BBSome traffic were apparently normal in arl13. However, transport of PLD, which in control cells moves by BBSome-dependent IFT, was impaired in arl13, causing PLD to accumulate in cilia. ARL13 only rarely and transiently traveled by IFT, indicating that it is not a co-migrating adapter securing PLD to IFT trains. In conclusion, the loss of Chlamydomonas ARL13 impedes BBSome-dependent protein transport, resulting in overlapping biochemical defects in arl13 and bbs mutant cilia.","journal":"The Journal of Cell Biology","year":2022,"id":256722,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":662219,"name":"Gui Zhang","orcid":"0000-0002-1123-7877","position":1,"is_corresponding":false},{"id":831794,"name":"Rama A. Alkhofash","orcid":null,"position":2,"is_corresponding":false},{"id":698843,"name":"Betlehem Mekonnen","orcid":null,"position":3,"is_corresponding":false},{"id":906595,"name":"Sahana Saravanan","orcid":null,"position":4,"is_corresponding":false},{"id":309341,"name":"Bin Xue","orcid":"0000-0002-7256-1179","position":5,"is_corresponding":false},{"id":309348,"name":"Zhen‐Chuan Fan","orcid":"0000-0003-1712-3413","position":6,"is_corresponding":false},{"id":906596,"name":"Ewelina Betleja","orcid":null,"position":7,"is_corresponding":false},{"id":906597,"name":"Douglas G. Cole","orcid":null,"position":8,"is_corresponding":false},{"id":320832,"name":"Peiwei Liu","orcid":"0000-0001-5597-2200","position":9,"is_corresponding":false},{"id":309347,"name":"Karl F. Lechtreck","orcid":"0000-0002-6219-6470","position":10,"is_corresponding":false},{"id":831332,"name":"Jin Dai","orcid":"0000-0001-8770-0816","position":0,"is_corresponding":true}],"reference_count":96,"raw_metadata":null,"created_at":"2026-07-19T00:25:25.728895Z","pmid":"36040375","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}