{"doi":"10.1083/jcb.202110057","title":"JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport","abstract":"The MAP kinase and motor scaffold JIP3 prevents excess lysosome accumulation in axons of vertebrates and invertebrates. How JIP3's interaction with dynein and kinesin-1 contributes to organelle clearance is unclear. We show that human dynein light intermediate chain (DLIC) binds the N-terminal RH1 domain of JIP3, its paralog JIP4, and the lysosomal adaptor RILP. A point mutation in RH1 abrogates DLIC binding without perturbing the interaction between JIP3's RH1 domain and kinesin heavy chain. Characterization of this separation-of-function mutation in Caenorhabditis elegans shows that JIP3-bound dynein is required for organelle clearance in the anterior process of touch receptor neurons. Unlike JIP3 null mutants, JIP3 that cannot bind DLIC causes prominent accumulation of endo-lysosomal organelles at the neurite tip, which is rescued by a disease-associated point mutation in JIP3's leucine zipper that abrogates kinesin light chain binding. These results highlight that RH1 domains are interaction hubs for cytoskeletal motors and suggest that JIP3-bound dynein and kinesin-1 participate in bidirectional organelle transport.","journal":"The Journal of Cell Biology","year":2022,"id":238348,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":862038,"name":"José B. Gama","orcid":"0000-0002-7011-1502","position":1,"is_corresponding":false},{"id":862039,"name":"Artur F. Castro-Rodrigues","orcid":"0000-0002-1630-3810","position":2,"is_corresponding":false},{"id":695070,"name":"Daniel José Barbosa","orcid":"0000-0002-1726-6011","position":3,"is_corresponding":false},{"id":862040,"name":"Hélder Rocha","orcid":"0000-0003-1062-2498","position":4,"is_corresponding":false},{"id":862041,"name":"Ennio d’Amico","orcid":"0000-0002-1451-6273","position":5,"is_corresponding":false},{"id":862042,"name":"Andrea Musacchio","orcid":"0000-0003-2362-8784","position":6,"is_corresponding":false},{"id":201937,"name":"Ana X. Carvalho","orcid":"0000-0002-2256-7134","position":7,"is_corresponding":false},{"id":51701,"name":"João H. Morais‐Cabral","orcid":"0000-0002-4461-9716","position":8,"is_corresponding":false},{"id":598720,"name":"Reto Gassmann","orcid":"0000-0002-0360-2977","position":9,"is_corresponding":false},{"id":862037,"name":"Ricardo Celestino","orcid":"0000-0002-9605-6433","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T00:22:26.932537Z","pmid":"35829703","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}