{"doi":"10.1083/jcb.202105177","title":"How the vacuole ESCRTs its own proteins to their final destination","abstract":"<jats:p>Lysosomes (vacuoles in yeast) are master regulators of metabolism and protein turnover, but how they degrade their own resident proteins is unclear. Recently, multiple models have been proposed explaining yeast vacuole protein sorting, but the role of the ESCRT pathway was unclear. In this JCB issue, work from Yang et al. (https://doi.org/10.1083/jcb.202012104) highlights how the ESCRT pathway localizes to the vacuole surface to execute protein sorting of its resident proteins.</jats:p>","journal":"Journal of Cell Biology","year":2021,"id":37900,"datarank":0.26262951821889413,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.05468536405091054,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.05468536405091054,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":188970,"name":"W. Mike Henne","orcid":"0000-0002-2135-2799","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34279549","pmcid":"PMC8292134","openalex_id":"https://openalex.org/W3186402253","authors":[],"funders":[{"funder_name":"National Institute of General Medical Sciences","grant_id":"GM119768","title":null},{"funder_name":"National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"DK126887","title":null},{"funder_name":"Welch Foundation","grant_id":"I-1873","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R35 GM119768","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK126887","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R35GM119768-03","title":"PXA domain-containing proteins in lysosome function and lipid metabolism"},{"funder_name":"National Institutes of Health","grant_id":"5R01DK126887-04","title":"Mechanisms of lipid droplet organization and functional diversification"},{"funder_name":"University of Texas Southwestern Medical Center","grant_id":"","title":null},{"funder_name":"Ara Parseghian Medical Research Fund","grant_id":"","title":null}],"total_grants":9,"fwci":0.2161,"citation_percentile":0.47517319,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2025,"count":1}],"oa_status":"bronze","license":"CC BY NC SA","oa_locations":[{"url":"https://rupress.org/jcb/article-pdf/220/8/e202105177/1419470/jcb_202105177.pdf","host_type":"journal"},{"url":"https://rupress.org/jcb/article-pdf/220/8/e202105177/1419470/jcb_202105177.pdf","host_type":"HYBRID"},{"url":"https://rupress.org/jcb/article-pdf/220/8/e202105177/1419470/jcb_202105177.pdf","host_type":"publisher"},{"url":"https://rupress.org/jcb/article-pdf/doi/10.1083/jcb.202105177/1838678/jcb_202105177.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1083/jcb.202105177","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34279549","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8292134","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8292134","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8292134?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1083/jcb.202105177","host_type":""},{"url":"https://dx.doi.org/10.1083/jcb.202105177","host_type":""}],"fields_of_study":["Cellular transport and secretion","Autophagy in Disease and Therapy","Endoplasmic Reticulum Stress and Disease","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Endosomal Sorting Complexes Required for Transport","Lysosomes","Protein Transport","Saccharomyces cerevisiae","Vacuoles"],"mesh_terms":["Lysosomes","Saccharomyces cerevisiae","Vacuoles","Protein Transport","Endosomal Sorting Complexes Required for Transport"],"keywords":["ESCRT","Vacuole","Protein targeting","Cell biology","Yeast","Vacuolar protein sorting","Saccharomyces cerevisiae","Biology","Transport protein","Biochemistry","Membrane protein","Endosome","Membrane","Cytoplasm","Protein Transport","Endosomal Sorting Complexes Required for Transport","Vacuoles","Spotlight","Lysosomes"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-10T21:39:01.275256Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}