{"doi":"10.1083/jcb.201912077","title":"FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply","abstract":"Mitochondrial movement and distribution are fundamental to their function. Here we report a mechanism that regulates mitochondrial movement by anchoring mitochondria to the F-actin cytoskeleton. This mechanism is activated by an increase in glucose influx and the consequent O-GlcNAcylation of TRAK (Milton), a component of the mitochondrial motor-adaptor complex. The protein four and a half LIM domains protein 2 (FHL2) serves as the anchor. FHL2 associates with O-GlcNAcylated TRAK and is both necessary and sufficient to drive the accumulation of F-actin around mitochondria and to arrest mitochondrial movement by anchoring to F-actin. Disruption of F-actin restores mitochondrial movement that had been arrested by either TRAK O-GlcNAcylation or forced direction of FHL2 to mitochondria. This pathway for mitochondrial immobilization is present in both neurons and non-neuronal cells and can thereby adapt mitochondrial dynamics to changes in glucose availability.","journal":"The Journal of Cell Biology","year":2021,"id":155576,"datarank":0.6166310796259968,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":0.0,"self_endowment_contribution":0.6166310796259968,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":471782,"name":"Gülçin Pekkurnaz","orcid":"0000-0002-7388-6178","position":1,"is_corresponding":false},{"id":658419,"name":"Jill E. Falk","orcid":"0000-0003-2910-9803","position":2,"is_corresponding":false},{"id":259632,"name":"Wei Wei","orcid":"0000-0001-8110-0705","position":3,"is_corresponding":false},{"id":579640,"name":"Morven Chin","orcid":"0000-0002-7578-1580","position":4,"is_corresponding":false},{"id":109120,"name":"Judith A. Steen","orcid":"0000-0002-8167-0772","position":5,"is_corresponding":false},{"id":451131,"name":"Thomas L. Schwarz","orcid":"0000-0001-7532-0250","position":6,"is_corresponding":false},{"id":451130,"name":"Himanish Basu","orcid":"0000-0001-8236-1157","position":0,"is_corresponding":true}],"reference_count":107,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:44:03.750995Z","pmid":"34342639","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}