{"doi":"10.1083/jcb.201910089","title":"Fam20C regulates protein secretion by Cab45 phosphorylation","abstract":"The TGN is a key compartment for the sorting and secretion of newly synthesized proteins. At the TGN, soluble proteins are sorted based on the instructions carried in their oligosaccharide backbones or by a Ca2+-mediated process that involves the cargo-sorting protein Cab45. Here, we show that Cab45 is phosphorylated by the Golgi-specific protein kinase Fam20C. Mimicking of phosphorylation translocates Cab45 into TGN-derived vesicles, which goes along with an increased export of LyzC, a Cab45 client. Our findings demonstrate that Fam20C plays a key role in the export of Cab45 clients by fine-tuning Cab45 oligomerization and thus impacts Cab45 retention in the TGN.","journal":"The Journal of Cell Biology","year":2020,"id":68354,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336985,"name":"Birgit Blank","orcid":"0000-0003-3954-4948","position":1,"is_corresponding":false},{"id":20987,"name":"Martin Steger","orcid":"0000-0003-1637-8190","position":2,"is_corresponding":false},{"id":362002,"name":"Víctor López","orcid":"0000-0003-1618-5786","position":3,"is_corresponding":false},{"id":363046,"name":"Gisela Beck","orcid":null,"position":4,"is_corresponding":false},{"id":336984,"name":"Bulat R. Ramazanov","orcid":"0000-0001-8335-3685","position":5,"is_corresponding":false},{"id":2937,"name":"Matthias Mann","orcid":"0000-0003-1292-4799","position":6,"is_corresponding":false},{"id":362003,"name":"Vincent S. Tagliabracci","orcid":"0000-0002-9735-4678","position":7,"is_corresponding":false},{"id":336987,"name":"Julia von Blume","orcid":"0000-0001-6665-1592","position":8,"is_corresponding":false},{"id":362001,"name":"Tobias Karl-Heinz Hecht","orcid":"0000-0001-9205-3318","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-18T21:40:52.680475Z","pmid":"32422653","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}