{"doi":"10.1083/jcb.201906148","title":"The postmitotic midbody: Regulating polarity, stemness, and proliferation","abstract":"<jats:p>Abscission, the final stage of cell division, requires well-orchestrated changes in endocytic trafficking, microtubule severing, actin clearance, and the physical sealing of the daughter cell membranes. These processes are highly regulated, and any missteps in localized membrane and cytoskeleton dynamics often lead to a delay or a failure in cell division. The midbody, a microtubule-rich structure that forms during cytokinesis, is a key regulator of abscission and appears to function as a signaling platform coordinating cytoskeleton and endosomal dynamics during the terminal stages of cell division. It was long thought that immediately following abscission and the conclusion of cell division, the midbody is either released or rapidly degraded by one of the daughter cells. Recently, the midbody has gained prominence for exerting postmitotic functions. In this review, we detail the role of the midbody in orchestrating abscission, as well as discuss the relatively new field of postabscission midbody biology, particularly focusing on how it may act to regulate cell polarity and its potential to regulate cell tumorigenicity or stemness.</jats:p>","journal":"Journal of Cell 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Peterman","orcid":"0000-0002-7635-6658","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.248495242049359,"endowment":4.248495242049359,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31690620","pmcid":"PMC6891101","openalex_id":"https://openalex.org/W2987451180","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"DK064380","title":null},{"funder_name":"National Institutes of Health","grant_id":"GM122768","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM122768","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK064380","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01DK064380-13","title":"Molecular Mechanisms of Polarized Endocytic Traffic in Epithelial Cells"},{"funder_name":"National Institutes of Health","grant_id":"5R01GM122768-07","title":"The mechanisms regulating actin dynamics and polarized membrane transport during cell migration"}],"total_grants":6,"fwci":3.8508,"citation_percentile":0.93772087,"influential_citations":3,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":4},{"year":2021,"count":8},{"year":2022,"count":21},{"year":2023,"count":14},{"year":2024,"count":9},{"year":2025,"count":9},{"year":2026,"count":2}],"oa_status":"bronze","license":"CC BY NC 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Mechanics and Interactions","Microtubule and mitosis dynamics","Cellular transport and secretion","Biology","Medicine","0301 basic medicine","0303 health sciences","03 medical and health sciences","Actins","Animals","Cell Division","Cell Line, Tumor","Cell Membrane","Cell Polarity","Cell Proliferation","Cytokinesis","Cytoskeleton","Endocytosis","Endosomal Sorting Complexes Required for Transport","Endosomes","HeLa Cells","Humans","Microtubules","Mitosis","Neoplasms","Phagocytes","Signal Transduction","Spindle Apparatus","Stem Cells"],"mesh_terms":["Actins","Animals","Cell Division","Cell Membrane","Cytoskeleton","Endocytosis","HeLa Cells","Humans","Microtubules","Mitosis","Spindle Apparatus","Neoplasms","Phagocytes","Endosomes","Stem Cells","Signal Transduction","Cell Polarity","Cell Line, Tumor","Cytokinesis","Cell Proliferation","Endosomal Sorting Complexes Required for Transport","Hela Cells"],"keywords":["Midbody","Cytokinesis","Cell biology","Abscission","Cell 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