{"doi":"10.1083/jcb.201903135","title":"Syncrip/hnRNP Q is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation","abstract":"Memory and learning involve activity-driven expression of proteins and cytoskeletal reorganization at new synapses, requiring posttranscriptional regulation of localized mRNA a long distance from corresponding nuclei. A key factor expressed early in synapse formation is Msp300/Nesprin-1, which organizes actin filaments around the new synapse. How Msp300 expression is regulated during synaptic plasticity is poorly understood. Here, we show that activity-dependent accumulation of Msp300 in the postsynaptic compartment of the Drosophila larval neuromuscular junction is regulated by the conserved RNA binding protein Syncrip/hnRNP Q. Syncrip (Syp) binds to msp300 transcripts and is essential for plasticity. Single-molecule imaging shows that msp300 is associated with Syp in vivo and forms ribosome-rich granules that contain the translation factor eIF4E. Elevated neural activity alters the dynamics of Syp and the number of msp300:Syp:eIF4E RNP granules at the synapse, suggesting that these particles facilitate translation. These results introduce Syp as an important early acting activity-dependent regulator of a plasticity gene that is strongly associated with human ataxias.","journal":"The Journal of Cell Biology","year":2020,"id":95140,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9419,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":473157,"name":"Francesca Robertson","orcid":"0000-0001-7157-5053","position":1,"is_corresponding":false},{"id":473158,"name":"Aino I. Järvelin","orcid":"0000-0002-1225-4396","position":2,"is_corresponding":false},{"id":473159,"name":"David Ish‐Horowicz","orcid":"0000-0001-5684-7129","position":3,"is_corresponding":false},{"id":473160,"name":"Carlas Smith","orcid":"0000-0003-0591-5093","position":4,"is_corresponding":false},{"id":239859,"name":"Enrico Gratton","orcid":"0000-0002-6450-7391","position":5,"is_corresponding":false},{"id":473161,"name":"Ilan Davis","orcid":"0000-0002-5385-3053","position":6,"is_corresponding":false},{"id":473156,"name":"Josh Titlow","orcid":"0000-0002-9586-4797","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-18T22:33:30.364261Z","pmid":"32040548","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}