{"doi":"10.1083/jcb.201609086","title":"Slip slidin’ away of mitosis with CRL2Zyg11","abstract":"<jats:p>The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphase-promoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601083) show that the E3 ligase CRL2ZYG11 degrades cyclin B1, allowing mitotic slippage.</jats:p>","journal":"Journal of Cell Biology","year":2016,"id":687906,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":76100,"name":"Michael Brandeis","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Slip slidin’ away of mitosis with CRL2Zyg11","abstract":"<jats:p>The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphase-promoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201601083) show that the E3 ligase CRL2ZYG11 degrades cyclin B1, allowing mitotic slippage.</jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27810907","pmcid":"PMC5084651","openalex_id":"https://openalex.org/W2536704947","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.09483904,"influential_citations":0,"citation_trend":[{"year":2020,"count":1}],"oa_status":"hybrid","license":"cc-by-nc-sa","oa_locations":[{"url":"https://doi.org/10.1083/jcb.201609086","host_type":"journal"},{"url":"https://doi.org/10.1083/jcb.201609086","host_type":"publisher"},{"url":"https://rupress.org/jcb/article-pdf/215/2/143/1603577/jcb_201609086.pdf","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27810907","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5084651","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5084651","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5084651?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Microtubule and mitosis dynamics","Protein Degradation and Inhibitors","Ubiquitin and proteasome pathways","Anaphase-Promoting Complex-Cyclosome","Animals","Cell Cycle Checkpoints","Cyclin B1","Humans","Microtubules","Mitosis","Spindle Apparatus","Ubiquitin-Protein Ligases"],"mesh_terms":["Animals","Humans","Microtubules","Mitosis","Spindle Apparatus","Ubiquitin-Protein Ligases","Cyclin B1","Cell Cycle Checkpoints","Anaphase-Promoting Complex-Cyclosome"],"keywords":["Mitosis","Biology","Anaphase-promoting complex","Cell biology","Cyclin B","Cyclin B1","Mitotic exit","Anaphase","Spindle checkpoint","Ubiquitin ligase","G2-M DNA damage checkpoint","Cyclin","Cell cycle","Cell cycle checkpoint","Spindle apparatus","Cell","Cell division","Cyclin-dependent kinase 1","Ubiquitin","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T09:26:11.461727Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}