{"doi":"10.1083/jcb.201111146","title":"Scoring a backstage pass: Mechanisms of ciliogenesis and ciliary access","abstract":"<jats:p>Cilia are conserved, microtubule-based cell surface projections that emanate from basal bodies, membrane-docked centrioles. The beating of motile cilia and flagella enables cells to swim and epithelia to displace fluids. In contrast, most primary cilia do not beat but instead detect environmental or intercellular stimuli. Inborn defects in both kinds of cilia cause human ciliopathies, diseases with diverse manifestations such as heterotaxia and kidney cysts. These diseases are caused by defects in ciliogenesis or ciliary function. The signaling functions of cilia require regulation of ciliary composition, which depends on the control of protein traffic into and out of cilia.</jats:p>","journal":"Journal of Cell Biology","year":2012,"id":599033,"datarank":0.8346780610984041,"base_score":5.564520407322694,"endowment":5.564520407322694,"self_citation_contribution":0.8346780610984041,"citation_network_contribution":0.0,"self_endowment_contribution":0.8346780610984041,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":260,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":74141,"name":"Jeremy F. Reiter","orcid":"0000-0002-6512-320X","position":1,"is_corresponding":false},{"id":1519900,"name":"Francesc R. Garcia-Gonzalo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Scoring a backstage pass: Mechanisms of ciliogenesis and ciliary access","abstract":"<jats:p>Cilia are conserved, microtubule-based cell surface projections that emanate from basal bodies, membrane-docked centrioles. The beating of motile cilia and flagella enables cells to swim and epithelia to displace fluids. In contrast, most primary cilia do not beat but instead detect environmental or intercellular stimuli. Inborn defects in both kinds of cilia cause human ciliopathies, diseases with diverse manifestations such as heterotaxia and kidney cysts. These diseases are caused by defects in ciliogenesis or ciliary function. The signaling functions of cilia require regulation of ciliary composition, which depends on the control of protein traffic into and out of cilia.</jats:p>","is_dataset_classified":null,"base_score":5.564520407322694,"endowment":5.564520407322694,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22689651","pmcid":"PMC3373398","openalex_id":"https://openalex.org/W2130801954","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM095941","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"AR054396","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM095941","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"R01 AR054396","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01AR054396-02","title":"Hedgehog signaling at the cell's antenna: Smoothened and the primary cilium"},{"funder_name":"National Institutes of Health","grant_id":"5R01GM095941-06","title":"Transition zone control of ciliary signaling"}],"total_grants":6,"fwci":17.0322,"citation_percentile":0.99462094,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":24},{"year":2014,"count":32},{"year":2015,"count":29},{"year":2016,"count":25},{"year":2017,"count":22},{"year":2018,"count":20},{"year":2019,"count":10},{"year":2020,"count":18},{"year":2021,"count":17},{"year":2022,"count":25},{"year":2023,"count":11},{"year":2024,"count":8},{"year":2025,"count":9},{"year":2026,"count":3}],"oa_status":"bronze","license":"CC BY NC SA","oa_locations":[{"url":"http://jcb.rupress.org/content/jcb/197/6/697.full.pdf","host_type":"journal"},{"url":"http://jcb.rupress.org/content/jcb/197/6/697.full.pdf","host_type":"publisher"},{"url":"https://rupress.org/jcb/article-pdf/197/6/697/1574098/jcb_201111146.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1083/jcb.201111146","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22689651","host_type":"repository"},{"url":"https://escholarship.org/uc/item/4k66q58v","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3373398","host_type":"repository"},{"url":"http://www.escholarship.org/uc/item/4k66q58v","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3373398","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3373398?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1083/jcb.201111146","host_type":""},{"url":"https://dx.doi.org/10.1083/jcb.201111146","host_type":""}],"fields_of_study":["Genetic and Kidney Cyst Diseases","Renal and related cancers","Hedgehog Signaling Pathway Studies","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Centrioles","Cilia","Humans","Membrane Proteins","Microtubules","Models, Biological","Cell Cycle Proteins"],"keywords":["Ciliogenesis","Cilium","Biology","Basal body","Ciliopathies","Centriole","Cell biology","Flagellum","Intraflagellar transport","Motile cilium","Microtubule","Ciliopathy","Centrosome","Bardet–Biedl syndrome","Cell","Phenotype","Genetics","Cell cycle","Gene","Reviews","Animals","Humans","Membrane Proteins","Cell Cycle Proteins","Cilia","Microtubules","Models, Biological","Centrioles"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T16:53:09.728033Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}