{"doi":"10.1083/jcb.200112092","title":"ARF-GAP–mediated interaction between the ER-Golgi v-SNAREs and the COPI coat","abstract":"<jats:p>In eukaryotic cells, secretion is achieved by vesicular transport. Fusion of such vesicles with the correct target compartment relies on SNARE proteins on both vesicle (v-SNARE) and the target membranes (t-SNARE). At present it is not clear how v-SNAREs are incorporated into transport vesicles. Here, we show that binding of ADP-ribosylation factor (ARF)–GTPase-activating protein (GAP) to ER-Golgi v-SNAREs is an essential step for recruitment of Arf1p and coatomer, proteins that together form the COPI coat. ARF-GAP acts catalytically to recruit COPI components. Inclusion of v-SNAREs into COPI vesicles could be mediated by direct interaction with the coat. The mechanisms by which v-SNAREs interact with COPI and COPII coat proteins seem to be different and may play a key role in determining specificity in vesicle budding.</jats:p>","journal":"The Journal of Cell Biology","year":2002,"id":16649,"datarank":4.421201057765636,"base_score":4.875197323201151,"endowment":4.875197323201151,"self_citation_contribution":0.7312795984801728,"citation_network_contribution":3.689921459285463,"self_endowment_contribution":0.7312795984801728,"citer_contribution":3.689921459285463,"corpus_percentile":null,"corpus_rank":null,"citation_count":130,"citer_count":110,"citers_with_citation_signal":87,"citers_with_endowment":87,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":122112,"name":"Uwe 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cargo."},{"funder_name":"Wellcome Trust","grant_id":"","title":null},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":3,"fwci":4.1631,"citation_percentile":0.94117647,"influential_citations":11,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":3},{"year":2014,"count":7},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2017,"count":5},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":4},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"bronze","license":"CC BY NC 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transport and secretion","Lipid Membrane Structure and Behavior","Calcium signaling and nucleotide metabolism","Biology","Medicine","Chemistry","0301 basic medicine","0303 health sciences","03 medical and health sciences","ADP-Ribosylation Factor 1","ADP-Ribosylation Factors","COP-Coated Vesicles","Coat Protein Complex I","DNA-Binding Proteins","Endoplasmic Reticulum","Fungal Proteins","GTPase-Activating Proteins","Intracellular Membranes","Membrane Proteins","Microsomes","Protein Binding","Recombinant Fusion Proteins","SNARE Proteins","Saccharomyces cerevisiae Proteins","Vesicular Transport Proteins"],"mesh_terms":["DNA-Binding Proteins","Endoplasmic Reticulum","Fungal Proteins","Intracellular Membranes","Membrane Proteins","Microsomes","Protein Binding","Recombinant Fusion Proteins","GTPase-Activating Proteins","ADP-Ribosylation Factors","Coat Protein Complex I","ADP-Ribosylation Factor 1","COP-Coated Vesicles","Saccharomyces cerevisiae Proteins","Vesicular Transport Proteins","SNARE Proteins"],"keywords":["COPI","COPII","Cell biology","Biology","Vesicle","Golgi apparatus","ADP ribosylation factor","Vesicular Transport Proteins","Vesicular transport protein","GTPase","Secretory pathway","Endosome","Endoplasmic reticulum","Membrane","Biochemistry","Saccharomyces cerevisiae Proteins","ADP-Ribosylation Factors","Recombinant Fusion Proteins","GTPase-Activating Proteins","Membrane Proteins","Intracellular Membranes","Article","Coat Protein Complex I","DNA-Binding Proteins","Fungal Proteins","Microsomes","ADP-Ribosylation Factor 1","COP-Coated Vesicles","SNARE Proteins","Protein 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