{"doi":"10.1083/jcb.109.1.409","title":"Integrin heterodimer and receptor complexity in avian and mammalian cells.","abstract":"<jats:p>We report data showing that the integrin receptor complex in chickens contains several discrete heterodimers all sharing the beta 1-integrin subunit combined separately with different alpha-subunits. Using antisera to synthetic peptides based on cDNA sequences of chicken and human alpha-integrin subunits to analyze the integrin complement of avian and mammalian cells, we show that band 2 of the chicken integrin complex contains alpha-subunits related to both alpha 3- and alpha 5-subunits of human integrins. alpha 3 beta 1 and alpha 5 beta 1 have both previously been shown in human cells to be fibronectin receptors and alpha 3 beta 1 can also act as a receptor for laminin and collagen. We also provide evidence for the presence, in band 1 of the chicken integrin complex, of a third integrin alpha-subunit which is also alpha 5 related. This integrin subunit exists in a separate heterodimer complex with beta 1 and binds to fibronectin-affinity columns. These results provide explanations for published data showing that the avian integrin complex contains receptor activity for a variety of extracellular matrix proteins. We conclude that the chicken integrin complex comprises a set of beta 1-integrin heterodimers equivalent to the human VLA antigens and includes at least two fibronectin receptors. Finally, we show that chicken embryo fibroblasts also contain a beta 3-class integrin related to the RGD receptors defined in various human cells.</jats:p>","journal":"The Journal of cell biology","year":1989,"id":19759,"datarank":9.506399639683549,"base_score":5.0238805208462765,"endowment":5.0238805208462765,"self_citation_contribution":0.7535820781269416,"citation_network_contribution":8.752817561556608,"self_endowment_contribution":0.7535820781269416,"citer_contribution":8.752817561556608,"corpus_percentile":null,"corpus_rank":null,"citation_count":151,"citer_count":131,"citers_with_citation_signal":126,"citers_with_endowment":126,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":132852,"name":"E E Marcantonio","orcid":null,"position":1,"is_corresponding":false},{"id":132853,"name":"M A Stepp","orcid":null,"position":2,"is_corresponding":false},{"id":132854,"name":"L A Urry","orcid":null,"position":3,"is_corresponding":false},{"id":132855,"name":"G H Yee","orcid":null,"position":4,"is_corresponding":false},{"id":132851,"name":"R O Hynes","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.0238805208462765,"endowment":5.0238805208462765,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2663881","pmcid":"PMC2115488","openalex_id":"https://openalex.org/W2108283255","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"F32CA08140","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA 17007","title":null},{"funder_name":"National Institutes of Health","grant_id":"5F32CA008140-03","title":"ANALYSIS OF THE FIBRONECTIN RECEPTOR IN FIBROBLASTS"}],"total_grants":3,"fwci":5.063,"citation_percentile":0.95821186,"influential_citations":2,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2019,"count":2},{"year":2023,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://rupress.org/jcb/article-pdf/109/1/409/1058231/409.pdf","host_type":"journal"},{"url":"https://rupress.org/jcb/article-pdf/109/1/409/1058231/409.pdf","host_type":"BRONZE"},{"url":"https://rupress.org/jcb/article-pdf/109/1/409/1058231/409.pdf","host_type":"publisher"},{"url":"https://rupress.org/jcb/article-pdf/109/1/409/1462321/409.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1083/jcb.109.1.409","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2663881","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2115488","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC2115488","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC2115488?pdf=render","host_type":"Europe_PMC"},{"url":"https://dx.doi.org/10.1083/jcb.109.1.409","host_type":""}],"fields_of_study":["Cell Adhesion Molecules Research","Monoclonal and Polyclonal Antibodies Research","RNA Interference and Gene Delivery","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Blotting, Western","Cell Adhesion","Chickens","Chromatography, Affinity","Cloning, Molecular","DNA","Fibronectins","Humans","Immunologic Techniques","Integrins","Ligands","Macromolecular Substances","Membrane Glycoproteins","Molecular Sequence Data","Molecular Weight","Multigene Family"],"mesh_terms":["Animals","Cell Adhesion","Chickens","Chromatography, Affinity","Cloning, Molecular","DNA","Fibronectins","Multigene Family","Humans","Immunologic Techniques","Ligands","Membrane Glycoproteins","Molecular Sequence Data","Molecular Weight","Blotting, Western","Integrins","Macromolecular Substances"],"keywords":["Integrin","Integrin, beta 6","CD49c","Collagen receptor","Biology","Integrin alpha M","Fibronectin","Vitronectin","Laminin","Cell biology","Protein subunit","Molecular biology","Alpha-v beta-3","Receptor","Alpha (finance)","Extracellular matrix","Biochemistry","Gene","Integrins","Membrane Glycoproteins","Macromolecular Substances","Blotting, Western","Molecular Sequence Data","DNA","Ligands","Chromatography, Affinity","Fibronectins","Molecular Weight","Multigene Family","Cell Adhesion","Immunologic Techniques","Animals","Humans","Cloning, Molecular","Chickens"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-04T05:44:37.957012Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}