{"doi":"10.1080/24701394.2017.1325480","title":"Mitochondrial DNA heteroplasmy in cardiac tissue from individuals with and without coronary artery disease","abstract":null,"journal":"Mitochondrial DNA Part A","year":2018,"id":680750,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1778588,"name":"Javier Guillermo Blanco","orcid":null,"position":1,"is_corresponding":false},{"id":1778587,"name":"Erik Hefti","orcid":"0000-0003-0358-2539","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mitochondrial DNA heteroplasmy in cardiac tissue from individuals with and without coronary artery disease","abstract":"The cellular environment associated with coronary artery disease (CAD) can lead to mitochondrial DNA (mtDNA) damage. Mitochondrial variants in some copies of mtDNA (heteroplasmy) and mtDNA content are potential genetic biomarkers for CAD-associated disease states. Massively parallel sequencing and qRT-PCR techniques were used to measure heteroplasmic variants and mtDNA content in heart samples from donors with (n = 8) and without (n = 7) documented CAD. Both groups showed increased numbers of heteroplasmic mtDNA variants in the control region (CR) (p < .0010, ANOVA). The donors with CAD displayed a 41.07% increase in heteroplasmic mtDNA variant number in the CR (p = .043), an 87.50% increase in the number of heteroplasmic mtDNA deletions (p = .12), and a 48.76% increase in the number of heteroplasmic mtDNA single nucleotide variants (p = .029). These data suggest potential trends towards higher cardiac mtDNA heteroplasmy levels in heart samples from donors with CAD.","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28521548","pmcid":"PMC5694712","openalex_id":"https://openalex.org/W2615662934","authors":[],"funders":[{"funder_name":"National Institute of General Medical Sciences","grant_id":"R01GM073646","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR001412","title":null}],"total_grants":2,"fwci":0.5066,"citation_percentile":0.62449676,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":4},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":2},{"year":2024,"count":4},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1080/24701394.2017.1325480","host_type":"publisher"},{"url":"https://doi.org/10.1080/24701394.2017.1325480","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28521548","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5694712","host_type":"repository"}],"fields_of_study":["Mitochondrial Function and Pathology","Metabolism and Genetic Disorders","ATP Synthase and ATPases Research","Adult","Aged","Aged, 80 and over","Case-Control Studies","Coronary Artery Disease","DNA, Mitochondrial","Female","Genetic Variation","Genome, Mitochondrial","High-Throughput Nucleotide Sequencing","Humans","Male","Middle Aged","Mitochondria, Heart","Sequence Analysis, DNA","Young Adult"],"mesh_terms":["Adult","Aged","Aged, 80 and over","Coronary Artery Disease","DNA, Mitochondrial","Female","Humans","Male","Middle Aged","Mitochondria, Heart","Genetic Variation","Case-Control Studies","Sequence Analysis, DNA","Genome, Mitochondrial","Young Adult","High-Throughput Nucleotide Sequencing"],"keywords":["Heteroplasmy","Mitochondrial DNA","Biology","Genetics","Coronary artery disease","Internal medicine","Medicine","Gene","Mitochondria","Mitochondrial Variation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T16:01:07.405182Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}