{"doi":"10.1080/21623945.2023.2268261","title":"Matrix density regulates adipocyte phenotype","abstract":"Alterations of the extracellular matrix contribute to adipose tissue dysfunction in metabolic disease. We studied the role of matrix density in regulating human adipocyte phenotype in a tunable hydrogel culture system. Lipid accumulation was maximal in intermediate hydrogel density of 5 weight %, relative to 3% and 10%. Adipogenesis and lipid and oxidative metabolic gene pathways were enriched in adipocytes in 5% relative to 3% hydrogels, while fibrotic gene pathways were enriched in 3% hydrogels. These data demonstrate that the intermediate density matrix promotes a more adipogenic, less fibrotic adipocyte phenotype geared towards increased lipid and aerobic metabolism. These observations contribute to a growing literature describing the role of matrix density in regulating adipose tissue function.","journal":"Adipocyte","year":2023,"id":364651,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1033067,"name":"Atticus J. McCoy","orcid":"0000-0003-2736-8780","position":1,"is_corresponding":false},{"id":319904,"name":"Carmen G. Flesher","orcid":"0009-0003-8984-8015","position":2,"is_corresponding":false},{"id":367183,"name":"Nicole E. Friend","orcid":"0000-0001-5090-6538","position":3,"is_corresponding":false},{"id":104811,"name":"Jie Li","orcid":"0000-0003-0973-8645","position":4,"is_corresponding":false},{"id":1120225,"name":"Kore Akinleye","orcid":null,"position":5,"is_corresponding":false},{"id":1119756,"name":"Christopher Patsalis","orcid":"0009-0003-4585-0017","position":6,"is_corresponding":false},{"id":277960,"name":"Carey N. Lumeng","orcid":"0000-0003-0303-6204","position":7,"is_corresponding":false},{"id":367191,"name":"Andrew J. Putnam","orcid":"0000-0002-1262-4377","position":8,"is_corresponding":false},{"id":319905,"name":"Robert W. O’Rourke","orcid":"0000-0002-4038-4198","position":9,"is_corresponding":false},{"id":664036,"name":"Alexander Ky","orcid":null,"position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T01:14:41.218128Z","pmid":"37815174","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}