{"doi":"10.1080/21623945.2020.1798632","title":"Circulating microRNA changes in patients with impaired glucose regulation","abstract":"We analysed if levels of four miRNAs would change after a lifestyle intervention involving dietary and exercises in prediabetes. MiRNAs previously shown to be associated with diabetes (Let-7a, Let-7e, miR-144 and miR-92a) were extracted from serum pre- and post-intervention. mRNA was extracted from fat-tissue for gene expression analyses. The intervention resulted in increased Let-7a and miR-92a. We found correlations between miRNAs and clinical variables (triglycerides, cholesterol, insulin, weight and BMI). We also found correlations between miRNAs and target genes, revealing a link between miR-92a and IGF system. A lifestyle intervention resulted in marked changes in miRNAs. The association of miRNAs with insulin and the IGF system (both receptors and binding proteins) may represent a mechanism of regulating IGFs metabolic actions.","journal":"Adipocyte","year":2020,"id":87014,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":443240,"name":"Camila Marcelino Loureiro","orcid":"0000-0002-0239-5064","position":1,"is_corresponding":false},{"id":443241,"name":"Kirk Siddals","orcid":"0000-0002-4647-3140","position":2,"is_corresponding":false},{"id":443242,"name":"Caroline Dalton","orcid":"0000-0002-1404-873X","position":3,"is_corresponding":false},{"id":443243,"name":"Gavin P. Reynolds","orcid":"0000-0001-9026-7726","position":4,"is_corresponding":false},{"id":334382,"name":"Martin Gibson","orcid":"0000-0002-1331-1524","position":5,"is_corresponding":false},{"id":297552,"name":"Zhen Chen","orcid":"0000-0002-3291-1090","position":6,"is_corresponding":false},{"id":443244,"name":"Adrian Heald","orcid":"0000-0002-9537-4050","position":7,"is_corresponding":false},{"id":443239,"name":"Helene Fachim","orcid":"0000-0003-3818-3167","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-18T21:59:31.247492Z","pmid":"32752917","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}