{"doi":"10.1080/21623945.2018.1453769","title":"What activates thermogenesis when lipid droplet lipolysis is absent in brown adipocytes?","abstract":null,"journal":"Adipocyte","year":2018,"id":599168,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1034737,"name":"Hang Shi","orcid":"0000-0003-2330-7438","position":1,"is_corresponding":false},{"id":564928,"name":"Bingzhong Xue","orcid":"0000-0002-7857-1343","position":2,"is_corresponding":false},{"id":564927,"name":"Liqing Yu","orcid":"0000-0002-5186-9182","position":3,"is_corresponding":false},{"id":178870,"name":"Hyunsu Shin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"What activates thermogenesis when lipid droplet lipolysis is absent in brown adipocytes?","abstract":"Cold exposure activates the sympathetic nervous system. It is generally thought that this sympathetic activation induces heat production by stimulating lipolysis of cytosolic lipid droplets (LDs) in brown adipocytes. However, this concept was not examined in vivo due to lack of appropriate animal models. Recently, we and others have demonstrated that LD lipolysis in brown adipocytes is not required for cold-induced nonshivering thermogenesis. Our studies uncovered an essential role of white adipose tissue (WAT) lipolysis in fueling thermogenesis during fasting. In addition, we showed that lipolysis deficiency in brown adipose tissue (BAT) induces WAT browning. This commentary further discusses the significance of our findings and how whole body may be heated up without BAT lipolysis.","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29620433","pmcid":"PMC6152517","openalex_id":"https://openalex.org/W2792813271","authors":[],"funders":[{"funder_name":"American Diabetes Association Research Foundation","grant_id":"1-18-IBS-346","title":null},{"funder_name":"American Diabetes Association Research Foundation","grant_id":"7-13-IBS-159","title":null},{"funder_name":"American Heart Association","grant_id":"17GRNT33670590","title":null},{"funder_name":"National Heart, Lung, and Blood Institute","grant_id":"R01HL107500","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK111052","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK107544","title":null}],"total_grants":6,"fwci":2.17,"citation_percentile":0.8737596,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":5},{"year":2020,"count":7},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"gold","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1080/21623945.2018.1453769?needAccess=true","host_type":"journal"},{"url":"https://www.tandfonline.com/doi/pdf/10.1080/21623945.2018.1453769?needAccess=true","host_type":"publisher"},{"url":"https://www.tandfonline.com/doi/pdf/10.1080/21623945.2018.1453769","host_type":"publisher"},{"url":"https://doi.org/10.1080/21623945.2018.1453769","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29620433","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6152517","host_type":"repository"}],"fields_of_study":["Adipose Tissue and Metabolism","Lipid metabolism and biosynthesis","Exercise and Physiological Responses"],"mesh_terms":[],"keywords":["Lipolysis","Thermogenesis","Brown adipose tissue","Internal medicine","Endocrinology","White adipose tissue","Lipid droplet","Adipose tissue","Chemistry","Biology","Medicine","Glucose","Fatty acid","Uncoupling protein 1","Sympathetic Innervation","White Adipose Tissue Browning"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T19:11:17.960985Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}