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Myosin light chains are calmodulin family members which are crucially involved in the mechanoenzymatic function of the myosin holoenzyme. This review examines the diversity of light chains within the myosin superfamily, discusses interactions between the light chain and the myosin heavy chain as well as regulatory and structural functions of the light chain as a subunit of the myosin holoenzyme. It covers aspects of the myosin light chain in the localization of the myosin holoenzyme, protein-protein interactions and light chain binding to non-myosin binding partners. Finally, this review challenges the dogma that myosin regulatory and essential light chain exclusively associate with conventional myosin heavy chains while unconventional myosin heavy chains usually associate with calmodulin.","is_dataset_classified":null,"base_score":5.0238805208462765,"endowment":5.0238805208462765,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26155737","pmcid":"PMC4914028","openalex_id":"https://openalex.org/W1546918094","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"HL001786","title":null},{"funder_name":"National Institutes of Health","grant_id":"1ZIAHL001786-42","title":"Regulation Of Smooth and Nonmuscle Myosin"},{"funder_name":"Intramural NIH HHS","grant_id":"","title":null},{"funder_name":"Intramural NIH HHS","grant_id":"","title":null}],"total_grants":4,"fwci":2.2488,"citation_percentile":0.88269315,"influential_citations":0,"citation_trend":[{"year":2016,"count":5},{"year":2017,"count":7},{"year":2018,"count":14},{"year":2019,"count":13},{"year":2020,"count":20},{"year":2021,"count":13},{"year":2022,"count":26},{"year":2023,"count":19},{"year":2024,"count":16},{"year":2025,"count":8},{"year":2026,"count":10}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1080/19490992.2015.1054092?needAccess=true","host_type":"journal"},{"url":"https://www.tandfonline.com/doi/pdf/10.1080/19490992.2015.1054092?needAccess=true","host_type":"publisher"},{"url":"https://www.tandfonline.com/doi/pdf/10.1080/19490992.2015.1054092","host_type":"publisher"},{"url":"https://doi.org/10.1080/19490992.2015.1054092","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26155737","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4914028","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4914028","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4914028?pdf=render","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/pmc4914028?pdf=render","host_type":""},{"url":"http://dx.doi.org/10.1080/19490992.2015.1054092","host_type":""},{"url":"https://dx.doi.org/10.1080/19490992.2015.1054092","host_type":""}],"fields_of_study":["Cardiomyopathy and Myosin Studies","Muscle Physiology and Disorders","Cardiovascular Effects of Exercise","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Humans","Models, Molecular","Muscle Contraction","Muscles","Myosin Light Chains","Protein Binding","Protein Conformation","Protein Isoforms","Signal Transduction","Structure-Activity Relationship"],"mesh_terms":["Animals","Humans","Models, Molecular","Muscle Contraction","Muscles","Protein Binding","Protein Conformation","Structure-Activity Relationship","Signal Transduction","Myosin Light Chains","Protein Isoforms"],"keywords":["Myosin","Myosin light-chain kinase","Immunoglobulin light chain","Calmodulin","Protein subunit","Myosin head","Heavy chain","Biophysics","Cell biology","Biology","Chemistry","Biochemistry","Enzyme","Genetics","Gene","Actin","Cytoskeleton","Live Cell Imaging","Essential Light Chain","Regulatory Light Chain","Models, Molecular","Myosin Light Chains","Protein Conformation","Muscles","Review","Structure-Activity Relationship","Animals","Humans","Protein Isoforms","Muscle Contraction","Protein Binding","Signal Transduction"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T18:38:01.403138Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}