{"doi":"10.1080/19490976.2025.2601430","title":"Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation","abstract":"Microbiome-based therapies are promising new treatment avenues. While global alterations in microbiota composition have been shown in multiple sclerosis, whether and how gut microbiota influence autoimmune responses in an antigen-specific manner is unclear. Here, we genetically engineered gut bacteria to express a brain antigen and dissect their pathogenic potential in a murine model of autoimmune neuroinflammation. Colonization with bacteria expressing myelin - but not ovalbumin-peptide exacerbates an encephalitogenic immune response in the gut by activating antigen-specific T cells as well as B cells leading to accelerated neuroinflammatory disease. These results demonstrate how antigen-specific microbial modulation can influence autoimmunity, providing insight for development of therapeutic strategies targeting specific bacterial taxa for treatment of MS and other autoimmune diseases.","journal":"Gut Microbes","year":2025,"id":549713,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1444464,"name":"Kristina Berve","orcid":"0009-0006-1680-7222","position":1,"is_corresponding":false},{"id":1444465,"name":"Elisabeth Pössnecker","orcid":"0000-0002-6271-2404","position":2,"is_corresponding":false},{"id":467233,"name":"Julia Dyckow","orcid":"0000-0003-1423-9322","position":3,"is_corresponding":false},{"id":870111,"name":"Amel Zulji","orcid":"0000-0002-5185-1898","position":4,"is_corresponding":false},{"id":468448,"name":"Ryan Baumann","orcid":null,"position":5,"is_corresponding":false},{"id":1444466,"name":"Aida Muñoz-Blázquez","orcid":"0000-0003-1009-8593","position":6,"is_corresponding":false},{"id":1444467,"name":"Gurumoorthy Krishnamoorthy","orcid":"0000-0002-7798-6707","position":7,"is_corresponding":false},{"id":815054,"name":"David Schreiner","orcid":"0000-0003-0324-2526","position":8,"is_corresponding":false},{"id":805146,"name":"Sharon A. Sagan","orcid":"0009-0008-2212-5783","position":9,"is_corresponding":false},{"id":1444843,"name":"Charlotte Nelson","orcid":null,"position":10,"is_corresponding":false},{"id":246846,"name":"Joseph J. Sabatino","orcid":"0000-0002-6804-7441","position":11,"is_corresponding":false},{"id":808104,"name":"Kazuki Nagashima","orcid":"0000-0002-8593-136X","position":12,"is_corresponding":false},{"id":669573,"name":"Médéric Diard","orcid":"0000-0001-5914-8059","position":13,"is_corresponding":false},{"id":97010,"name":"A Macpherson","orcid":null,"position":14,"is_corresponding":false},{"id":879668,"name":"Stephanie C. Ganal‐Vonarburg","orcid":"0000-0002-2548-7754","position":15,"is_corresponding":false},{"id":806326,"name":"Michael A. Fischbach","orcid":"0000-0002-9203-4026","position":16,"is_corresponding":false},{"id":246282,"name":"Scott S. Zamvil","orcid":"0000-0003-2720-9915","position":17,"is_corresponding":false},{"id":29910,"name":"Lucas Schirmer","orcid":"0000-0001-7142-4116","position":18,"is_corresponding":false},{"id":1310,"name":"Sergio E. Baranzini","orcid":"0000-0003-0067-194X","position":19,"is_corresponding":false},{"id":1444844,"name":"Anne-Katrin Pröbstel","orcid":null,"position":20,"is_corresponding":false},{"id":1444463,"name":"Lena K. Siewert","orcid":"0000-0003-3808-3377","position":0,"is_corresponding":true}],"reference_count":81,"raw_metadata":null,"created_at":"2026-07-19T02:54:12.321988Z","pmid":"41437842","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}