{"doi":"10.1080/15622975.2018.1449966","title":"Familial abnormalities of endocannabinoid signaling in schizophrenia","abstract":null,"journal":"The World Journal of Biological Psychiatry","year":2019,"id":666482,"datarank":0.5709993734655481,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":0.0,"self_endowment_contribution":0.5709993734655481,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1740493,"name":"Franziska Pahlisch","orcid":"0000-0003-0167-3832","position":1,"is_corresponding":false},{"id":374870,"name":"Martin Hellmich","orcid":"0000-0001-5174-928X","position":2,"is_corresponding":false},{"id":1740495,"name":"Cathrin Rohleder","orcid":"0000-0002-3559-1846","position":3,"is_corresponding":false},{"id":1740497,"name":"Juliane K. Mueller","orcid":null,"position":4,"is_corresponding":false},{"id":34999,"name":"Andreas Meyer‐Lindenberg","orcid":"0000-0001-5619-1123","position":5,"is_corresponding":false},{"id":1740500,"name":"E. Fuller Torrey","orcid":null,"position":6,"is_corresponding":false},{"id":397675,"name":"Daniele Piomelli","orcid":"0000-0002-2983-774X","position":7,"is_corresponding":false},{"id":664745,"name":"F. Markus Leweke","orcid":"0000-0002-8163-195X","position":8,"is_corresponding":false},{"id":1740492,"name":"Dagmar Koethe","orcid":"0000-0002-8324-6756","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Familial abnormalities of endocannabinoid signaling in schizophrenia","abstract":"OBJECTIVES: Epidemiological and experimental evidence suggests that the endocannabinoid system plays a pathophysiological role in schizophrenia. This is reflected by elevated cerebrospinal levels of the endocannabinoid anandamide in schizophrenia and its initial prodromal states. METHODS: We analyzed plasma concentrations of anandamide, 2-arachidonoyl-sn-glycerol, palmitoylethanolamide and oleoylethanolamide from 25 twin pairs discordant for schizophrenia, six discordant for bipolar disorder and eight healthy twin pairs to determine hereditary traits. RESULTS: Twin pairs discordant for schizophrenia or bipolar disorder had significantly higher levels of anandamide and palmitoylethanolamide compared to healthy twins (both P < 0.002). Non-affected twins discordant for schizophrenia, who developed a psychotic disorder within 5 years follow-up showed lower anandamide (P = 0.042) and 2-arachidonoyl-sn-glycerol levels (P = 0.049) than twins who remained healthy. CONCLUSIONS: We suggest that the protective upregulation of endocannabinoid signalling reflects either a hereditary trait or mirrors a modulating response to genetically influenced cerebral function involving, e.g., other neurotransmitters or energy metabolism.","is_dataset_classified":null,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29521179","pmcid":null,"openalex_id":"https://openalex.org/W2790867816","authors":[],"funders":[{"funder_name":"Stanley Medical Research Institute","grant_id":"01-315","title":null},{"funder_name":"Stanley Medical Research Institute","grant_id":"03-NV-003","title":null},{"funder_name":"Koeln Fortune Program","grant_id":"108-2000","title":null},{"funder_name":"Koeln Fortune Program","grant_id":"136-2007","title":null}],"total_grants":4,"fwci":2.3923,"citation_percentile":0.87779259,"influential_citations":0,"citation_trend":[{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":5},{"year":2021,"count":4},{"year":2022,"count":7},{"year":2023,"count":5},{"year":2024,"count":13},{"year":2025,"count":4}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1080/15622975.2018.1449966","host_type":"publisher"},{"url":"https://doi.org/10.1080/15622975.2018.1449966","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29521179","host_type":"repository"},{"url":"https://kups.ub.uni-koeln.de/15682/","host_type":"repository"}],"fields_of_study":["Cannabis and Cannabinoid Research","Forensic Toxicology and Drug Analysis","Neuroscience of respiration and sleep","Adult","Amides","Arachidonic Acids","Bipolar Disorder","Endocannabinoids","Ethanolamines","Female","Genetic Predisposition to Disease","Glycerides","Humans","Male","Middle Aged","Palmitic Acids","Polyunsaturated Alkamides","Prodromal Symptoms","Psychotic Disorders","Schizophrenia","Signal Transduction","Up-Regulation","Young Adult"],"mesh_terms":["Adult","Amides","Arachidonic Acids","Bipolar Disorder","Ethanolamines","Female","Glycerides","Humans","Male","Middle Aged","Palmitic Acids","Psychotic Disorders","Schizophrenia","Signal Transduction","Up-Regulation","Genetic Predisposition to Disease","Polyunsaturated Alkamides","Young Adult","Prodromal Symptoms","Endocannabinoids"],"keywords":["Endocannabinoid system","Anandamide","Palmitoylethanolamide","Schizophrenia (object-oriented programming)","Internal medicine","Endocrinology","Bipolar disorder","Offspring","Neuroscience","Medicine","Psychology","Cannabinoid receptor","Psychiatry","Biology","Lithium (medication)","Genetics","Pregnancy","Receptor","Psychosis","Endocannabinoids","Monozygotic Twins","Genetic Risk","Anandamide (Aea)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T14:35:40.534155Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}