{"doi":"10.1080/15548627.2024.2370751","title":"(-)-Epigallocatechin 3-gallate protects pancreatic β-cell against excessive autophagy-induced injury through promoting FTO degradation","abstract":null,"journal":"Autophagy","year":2024,"id":654703,"datarank":0.519860385419959,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.0,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":621756,"name":"Yuhan Zhang","orcid":"0000-0003-1225-0990","position":1,"is_corresponding":false},{"id":1708729,"name":"Suyun Zou","orcid":null,"position":2,"is_corresponding":false},{"id":356016,"name":"Jianan Wang","orcid":"0009-0007-8301-780X","position":3,"is_corresponding":false},{"id":1708730,"name":"Xirui Li","orcid":null,"position":4,"is_corresponding":false},{"id":1708731,"name":"Miaozhen Qin","orcid":null,"position":5,"is_corresponding":false},{"id":1708732,"name":"Liangjun Sun","orcid":null,"position":6,"is_corresponding":false},{"id":1708733,"name":"Wenyue Yin","orcid":null,"position":7,"is_corresponding":false},{"id":1685756,"name":"Xiaoai Chang","orcid":null,"position":8,"is_corresponding":false},{"id":651124,"name":"Shusen Wang","orcid":"0000-0002-2323-6564","position":9,"is_corresponding":false},{"id":435553,"name":"Xiao Han","orcid":"0000-0001-6749-1877","position":10,"is_corresponding":false},{"id":1708734,"name":"Tijun Wu","orcid":null,"position":11,"is_corresponding":false},{"id":789032,"name":"Fang Chen","orcid":"0000-0001-7019-8620","position":12,"is_corresponding":false},{"id":945384,"name":"Yixue Shao","orcid":"0000-0003-1410-5455","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"(-)-Epigallocatechin 3-gallate protects pancreatic β-cell against excessive autophagy-induced injury through promoting FTO degradation","abstract":"Excessive macroautophagy/autophagy leads to pancreatic β-cell failure that contributes to the development of diabetes. Our previous study proved that the occurrence of deleterious hyperactive autophagy attributes to glucolipotoxicity-induced NR3C1 activation. Here, we explored the potential protective effects of (-)-epigallocatechin 3-gallate (EGCG) on β-cell-specific NR3C1 overexpression mice in vivo and NR3C1-enhanced β cells in vitro. We showed that EGCG protects pancreatic β cells against NR3C1 enhancement-induced failure through inhibiting excessive autophagy. RNA demethylase FTO (FTO alpha-ketoglutarate dependent dioxygenase) caused diminished m6A modifications on mRNAs of three pro-oxidant genes (Tlr4, Rela, Src) and, hence, oxidative stress occurs; by contrast, EGCG promotes FTO degradation by the ubiquitin-proteasome system in NR3C1-enhanced β cells, which alleviates oxidative stress, and thereby prevents excessive autophagy. Moreover, FTO overexpression abolishes the beneficial effects of EGCG on β cells against NR3C1 enhancement-induced damage. Collectively, our results demonstrate that EGCG protects pancreatic β cells against NR3C1 enhancement-induced excessive autophagy through suppressing FTO-stimulated oxidative stress, which provides novel insights into the mechanisms for the anti-diabetic effect of EGCG.","is_dataset_classified":null,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38910554","pmcid":"PMC11572200","openalex_id":"https://openalex.org/W4399977822","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82330027","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82170810","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82370803","title":null}],"total_grants":3,"fwci":8.872,"citation_percentile":0.9854968,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":8},{"year":2026,"count":20}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11572200/pdf/KAUP_20_2370751.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11572200/pdf/KAUP_20_2370751.pdf","host_type":"repository"},{"url":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2024.2370751","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11572200","host_type":"repository"},{"url":"https://doi.org/10.1080/15548627.2024.2370751","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38910554","host_type":"repository"}],"fields_of_study":["Autophagy in Disease and Therapy","Tea Polyphenols and Effects","Advanced Glycation End Products research"],"mesh_terms":["Alpha-Ketoglutarate-Dependent Dioxygenase FTO","Animals","Autophagy","Catechin","Mice, Inbred C57BL","Oxidative Stress","Protective Agents","Insulin-Secreting Cells","Mice","Proteolysis"],"keywords":["Autophagy","Biology","Gallate","Degradation (telecommunications)","Cell biology","Epigallocatechin gallate","Cancer research","Apoptosis","Biochemistry","Pharmacology","Antioxidant","Polyphenol","Oxidative stress","Diabetes","Fto","Pancreatic Β-cell","(-)-Epigallocatechin 3-Gallate"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T07:55:41.218845Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}