{"doi":"10.1080/15548627.2016.1151580","title":"Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy","abstract":null,"journal":"Autophagy","year":2016,"id":670598,"datarank":0.9518454541242896,"base_score":6.345636360828596,"endowment":6.345636360828596,"self_citation_contribution":0.9518454541242896,"citation_network_contribution":0.0,"self_endowment_contribution":0.9518454541242896,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":569,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1031279,"name":"Ziheng Chen","orcid":"0000-0003-1918-106X","position":1,"is_corresponding":false},{"id":233115,"name":"Yueying Wang","orcid":"0000-0002-4204-0065","position":2,"is_corresponding":false},{"id":553076,"name":"Zheng Tan","orcid":null,"position":3,"is_corresponding":false},{"id":1751698,"name":"Chongzhuo Zhu","orcid":null,"position":4,"is_corresponding":false},{"id":1484766,"name":"Yanjun Li","orcid":"0000-0002-3688-5758","position":5,"is_corresponding":false},{"id":168113,"name":"Zhe Han","orcid":null,"position":6,"is_corresponding":false},{"id":1751699,"name":"Linbo Chen","orcid":null,"position":7,"is_corresponding":false},{"id":1605912,"name":"Ruize Gao","orcid":null,"position":8,"is_corresponding":false},{"id":392543,"name":"Lei Liu","orcid":"0000-0002-7009-8264","position":9,"is_corresponding":false},{"id":1374300,"name":"Quan Chen","orcid":"0000-0002-3543-2458","position":10,"is_corresponding":false},{"id":588975,"name":"Ming Chen","orcid":"0000-0003-2570-0858","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy","abstract":"Mitochondrial fragmentation due to imbalanced fission and fusion of mitochondria is a prerequisite for mitophagy, however, the exact \"coupling\" of mitochondrial dynamics and mitophagy remains unclear. We have previously identified that FUNDC1 recruits MAP1LC3B/LC3B (LC3) through its LC3-interacting region (LIR) motif to initiate mitophagy in mammalian cells. Here, we show that FUNDC1 interacts with both DNM1L/DRP1 and OPA1 to coordinate mitochondrial fission or fusion and mitophagy. OPA1 interacted with FUNDC1 via its Lys70 (K70) residue, and mutation of K70 to Ala (A), but not to Arg (R), abolished the interaction and promoted mitochondrial fission and mitophagy. Mitochondrial stress such as selenite or FCCP treatment caused the disassembly of the FUNDC1-OPA1 complex while enhancing DNM1L recruitment to the mitochondria. Furthermore, we observed that dephosphorylation of FUNDC1 under stress conditions promotes the dissociation of FUNDC1 from OPA1 and association with DNM1L. Our data suggest that FUNDC1 regulates both mitochondrial fission or fusion and mitophagy and mediates the \"coupling\" across the double membrane for mitochondrial dynamics and quality control.","is_dataset_classified":null,"base_score":6.345636360828596,"endowment":6.345636360828596,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27050458","pmcid":"PMC4836026","openalex_id":"https://openalex.org/W2322869984","authors":[],"funders":[],"total_grants":0,"fwci":12.0113,"citation_percentile":0.98977384,"influential_citations":0,"citation_trend":[{"year":2016,"count":7},{"year":2017,"count":21},{"year":2018,"count":19},{"year":2019,"count":28},{"year":2020,"count":64},{"year":2021,"count":62},{"year":2022,"count":80},{"year":2023,"count":67},{"year":2024,"count":83},{"year":2025,"count":98},{"year":2026,"count":39}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2016.1151580?needAccess=true&role=button","host_type":"journal"},{"url":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2016.1151580?needAccess=true&role=button","host_type":"publisher"},{"url":"http://www.tandfonline.com/doi/pdf/10.1080/15548627.2016.1151580","host_type":"publisher"},{"url":"https://doi.org/10.1080/15548627.2016.1151580","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27050458","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836026","host_type":"repository"}],"fields_of_study":["Mitochondrial Function and Pathology","Autophagy in Disease and Therapy","ATP Synthase and ATPases Research","Amino Acid Sequence","Casein Kinase II","Dynamins","GTP Phosphohydrolases","Gene Knockdown Techniques","HeLa Cells","Humans","Membrane Proteins","Microtubule-Associated Proteins","Mitochondria","Mitochondrial Dynamics","Mitochondrial Proteins","Mitophagy","Phosphorylation","Protein Binding"],"mesh_terms":["Amino Acid Sequence","HeLa Cells","Humans","Membrane Proteins","Microtubule-Associated Proteins","Mitochondria","Phosphorylation","Protein Binding","GTP Phosphohydrolases","Mitochondrial Proteins","Dynamins","Casein Kinase II","Gene Knockdown Techniques","Mitochondrial Dynamics","Mitophagy","Hela Cells"],"keywords":["Mitophagy","Mitochondrial fission","Biology","Cell biology","Mitochondrion","DNM1L","Autophagy","Genetics","Apoptosis","Mitochondrial Dynamics","Opa1","Mitophagy Receptor","Dnm1l/drp1"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-15T22:52:01.785201Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}