{"doi":"10.1080/15548627.2015.1009776","title":"Heat shock response and autophagy—cooperation and control","abstract":null,"journal":"Autophagy","year":2015,"id":685659,"datarank":0.8276179344697062,"base_score":5.517452896464707,"endowment":5.517452896464707,"self_citation_contribution":0.8276179344697062,"citation_network_contribution":0.0,"self_endowment_contribution":0.8276179344697062,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":248,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":3,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1791373,"name":"Orrin B Myers","orcid":null,"position":1,"is_corresponding":false},{"id":1715821,"name":"Pope L Moseley","orcid":null,"position":2,"is_corresponding":false},{"id":1715820,"name":"Karol Dokladny","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Heat shock response and autophagy—cooperation and control","abstract":"Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock proteins modulate protein folding and repair. At the other end, the proteasome and autophagy as well as other lysosome-dependent systems, function in the degradation of dysfunctional proteins. In this review, we examine how these systems interact to maintain proteostasis. Both the direct cellular data on heat shock control over autophagy and the time course of exercise-associated changes in humans support the model that heat shock response and autophagy are tightly linked. Studying the links between exercise stress and molecular control of proteostasis provides evidence that the heat shock response and autophagy coordinate and undergo sequential activation and downregulation, and that this is essential for proper proteostasis in eukaryotic systems.","is_dataset_classified":null,"base_score":5.517452896464707,"endowment":5.517452896464707,"datacite_reuse_total":3,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25714619","pmcid":"PMC4502786","openalex_id":"https://openalex.org/W1874817816","authors":[],"funders":[{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR001449","title":null}],"total_grants":1,"fwci":9.2244,"citation_percentile":0.98613283,"influential_citations":0,"citation_trend":[{"year":2015,"count":6},{"year":2016,"count":8},{"year":2017,"count":14},{"year":2018,"count":17},{"year":2019,"count":24},{"year":2020,"count":30},{"year":2021,"count":18},{"year":2022,"count":19},{"year":2023,"count":31},{"year":2024,"count":29},{"year":2025,"count":38},{"year":2026,"count":14}],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2015.1009776?needAccess=true","host_type":"journal"},{"url":"https://www.tandfonline.com/doi/pdf/10.1080/15548627.2015.1009776?needAccess=true","host_type":"publisher"},{"url":"http://www.tandfonline.com/doi/pdf/10.1080/15548627.2015.1009776","host_type":"publisher"},{"url":"https://doi.org/10.1080/15548627.2015.1009776","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25714619","host_type":"repository"},{"url":"https://curis.ku.dk/portal/da/publications/heat-shock-response-and-autophagy--cooperation-and-control(5384305d-9900-4822-825d-2242e7b6f4b8).html","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/5384305d-9900-4822-825d-2242e7b6f4b8","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4502786","host_type":"repository"},{"url":"https://curis.ku.dk/ws/files/233784569/Heat_shock_response_and_autophagy_cooperation_and_control.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4502786","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4502786?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Autophagy in Disease and Therapy","Endoplasmic Reticulum Stress and Disease","Lipid metabolism and biosynthesis","Animals","Autophagy","Heat-Shock Proteins","Heat-Shock Response","Humans","Lysosomes","Metabolic Networks and Pathways","Signal Transduction"],"mesh_terms":["Animals","Autophagy","Heat-Shock Proteins","Humans","Lysosomes","Signal Transduction","Heat-Shock Response","Metabolic Networks and Pathways"],"keywords":["Proteostasis","Autophagy","Cell biology","Biology","Heat shock","Heat shock protein","BAG3","Lysosome","Protein degradation","Protein folding","Proteasome","Biochemistry","Enzyme","Protein synthesis","Heat shock response","HSP70","Exercise","Humans","Er, Endoplasmic Reticulum","Il, Interleukin","Sod, Superoxide Dismutase","Protein Breakdown","Pbmc, Peripheral Blood Mononuclear Cell","Tpr, Translocated Promoter Region, Nuclear Basket Protein","Ppargc1a/pgc-1α, Peroxisome Proliferator-activated Receptor, Gamma, Coactivator 1 Α","Hsp, Heat Shock Protein","Ampk, Adenosine Monophosphate-activated Protein Kinase","Tsc, Tuberous Sclerosis Complex","Atg, Autophagy-related","Becn1, Beclin 1, Autophagy Related","Sqstm1/p62, Sequestosome 1","Ulk1, Unc-51 Like Autophagy Activating Kinase 1","Mtor, Mechanistic Target Of Rapamycin","Foxo, Forkhead Box O","Hspa8/hsc70, Heat Shock 70Kda Protein 8","Akt, V-akt Murine Thymoma Viral Oncogene Homolog 1","Eif4ebp1, Eukaryotic Translation Initiation Factor 4E Binding Protein 1","Hsf1, Heat Shock Transcription Factor 1","Lc3, Map1lc3, Microtubule-associated Protein 1 Light Chain 3","Mtmr14/hjumpy, Myotubularin Related Protein 14","Nr1d1/rev-erb-α, Nuclear Receptor Subfamily 1, Group D, Member 1","Rheb, Ras Homolog Enriched In Brain"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Partnerships for the goals"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.1317338.v1","title":"Heat shock response and autophagy—cooperation and control","publisher":"Taylor & 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