{"doi":"10.1080/15476286.2020.1860580","title":"Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy","abstract":"Pathological changes involving TDP-43 protein (‘TDP-43 proteinopathy’) are typical for several neurodegenerative diseases, including frontotemporal lobar degeneration (FTLD). FTLD-TDP cases are characterized by increased binding of TDP-43 to an abundant lncRNA, NEAT1, in the cortex. However it is unclear whether enhanced TDP-43-NEAT1 interaction represents a protective mechanism. We show that accumulation of human TDP-43 leads to upregulation of the constitutive NEAT1 isoform, NEAT1_1, in cultured cells and in the brains of transgenic mice. Further, we demonstrate that overexpression of NEAT1_1 ameliorates TDP-43 toxicity in Drosophila and yeast models of TDP-43 proteinopathy. Thus, NEAT1_1 upregulation may be protective in TDP-43 proteinopathies affecting the brain. Approaches to boost NEAT1_1 expression in the CNS may prove useful in the treatment of these conditions.","journal":"RNA Biology","year":2021,"id":163009,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":681684,"name":"Michail S. Kukharsky","orcid":"0000-0001-5080-2544","position":1,"is_corresponding":false},{"id":682657,"name":"Sei-Kyoung Park","orcid":null,"position":2,"is_corresponding":false},{"id":681685,"name":"Sangeun Park","orcid":"0000-0003-3898-6197","position":3,"is_corresponding":false},{"id":681686,"name":"Naruaki Watanabe","orcid":"0000-0002-7020-0222","position":4,"is_corresponding":false},{"id":55002,"name":"Takeshi Iwatsubo","orcid":"0000-0003-1160-8129","position":5,"is_corresponding":false},{"id":681687,"name":"Tadafumi Hashimoto","orcid":"0000-0001-5442-4800","position":6,"is_corresponding":false},{"id":681688,"name":"Susan W. Liebman","orcid":"0000-0002-5845-4633","position":7,"is_corresponding":false},{"id":681689,"name":"Tatyana A. Shelkovnikova","orcid":"0000-0003-1367-5309","position":8,"is_corresponding":false},{"id":682656,"name":"Koji Matsukawa","orcid":null,"position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T23:45:17.971865Z","pmid":"33427561","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}