{"doi":"10.1080/15216549600201083","title":"Attenuation by nicotinamide of the streptozocin induced early hyperglycaemia in fasting rats","abstract":"<jats:title>Abstract</jats:title><jats:p>The effect of nicotinamide on the streptozocin induced early hyperglycaemia in 48‐hour fasted rats was investigated. It was shown that 240 or 400 mg/kg nicotinamide significantly attenuated the streptozocin induced early hyperglycaemia. Nicotinamide should be administered no later than 1 hour after the streptozocin administration. Lower level doses of nicotinamide such as 80 mg/kg were unable to attenuate the streptozocin induced early hyperglycaemia. The possibility of nicotinamide offsetting the streptozocin effect was discussed.</jats:p>","journal":"IUBMB Life","year":1996,"id":16170,"datarank":0.2165297810838544,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.11255770399986259,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.11255770399986259,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":120367,"name":"Kai K. Wong","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8908360","pmcid":null,"openalex_id":"https://openalex.org/W1963751275","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.05479373,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://iubmb.onlinelibrary.wiley.com/doi/pdfdirect/10.1080/15216549600201083","host_type":"journal"},{"url":"https://iubmb.onlinelibrary.wiley.com/doi/pdfdirect/10.1080/15216549600201083","host_type":"BRONZE"},{"url":"https://iubmb.onlinelibrary.wiley.com/doi/pdfdirect/10.1080/15216549600201083","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1080%2F15216549600201083","host_type":"publisher"},{"url":"https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/15216549600201083","host_type":"publisher"},{"url":"https://doi.org/10.1080/15216549600201083","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8908360","host_type":"repository"}],"fields_of_study":["Pancreatic function and diabetes","Natural Antidiabetic Agents Studies","Bioactive natural compounds","Medicine","Animals","Antibiotics, Antineoplastic","Dose-Response Relationship, Drug","Fasting","Hyperglycemia","Male","Niacinamide","Rats","Rats, Sprague-Dawley","Streptozocin"],"mesh_terms":["Animals","Antibiotics, Antineoplastic","Dose-Response Relationship, Drug","Fasting","Hyperglycemia","Male","Niacinamide","Streptozocin","Rats, Sprague-Dawley","Rats"],"keywords":["Streptozocin","Nicotinamide","Endocrinology","Internal medicine","Medicine","Diabetes mellitus","Chemistry","Biochemistry","Streptozotocin","Enzyme"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T20:35:19.329125Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}